Catalog No.: PC-61631Not For Human Use, Lab Use Only.
ABTL0812 (2-hydroxylinoleic acid) is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells, binds to PPARα and PPARγ (Ki=7.1 and 4.7 uM, respectively).
ABTL0812 (Ibrilatazar) is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells, binds to PPARα and PPARγ (Ki=7.1 and 4.7 uM, respectively).
ABTL0812 induces PPARα and PPARγ transcriptional activities, and inhibits Akt phosphorylation by upregulating the expression of TRIB3.
ABTL0812 reduces viability of different human cancer cell lines (IC50=20-60 uM), induces autophagy-mediated cell death both in vitro and in vivo.
Physicochemical Properties
M.Wt
296.451
Formula
C18H32O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(9Z,12Z)-2-Hydroxy-9,12-octadecadienoic acid
References
1. Erazo T, et al. Clin Cancer Res. 2016 May 15;22(10):2508-19.
