AC1-IN-38

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Chemical Structure : AC1-IN-38

CAS No.: 2762422-55-7

Catalog No.: PC-72951Not For Human Use, Lab Use Only.

AC1-IN-38 is a potent, selective inhibitor of adenylyl cyclase type 1 (AC1) with IC50 of 0.54 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AC1-IN-38 is a potent, selective inhibitor of adenylyl cyclase type 1 (AC1) with IC50 of 0.54 uM.
AC1-IN-38 shows selectivity over a closely related isoform AC8, and no activity against AC2/5 and other common neurological targets.
AC1-IN-38 displayed modest antiallodynic effects in a mouse model of inflammatory pain.

Physicochemical Properties

M.Wt	355.373
Formula	C18H18FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(4-ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-3-methyl-1H-pyrazol-5-yl)-2-fluoro-5-methylbenzamide

References

1. Jason A. Scott, et al. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.1c01759

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AC1-IN-38

Biological Activity

Physicochemical Properties

References

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