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Chemical Structure : AC1115
Catalog No.: PC-21710Not For Human Use, Lab Use Only.
AC1115 is a potent, selective, next-generation antiviral targeting SARS-CoV-2 Mpro and host lysosomal cysteine protease cathepsin L (CTSL) with high antiviral activity, AC1115 is the active form of Olgotrelvir.
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AC1115 is a potent, selective, next-generation antiviral targeting SARS-CoV-2 Mpro and host lysosomal cysteine protease cathepsin L (CTSL) with high antiviral activity, AC1115 is the active form of Olgotrelvir.
AC1115 displays potent inhibition of both wild-type Mpro from the WA-1 strain and Omicron Mpro with IC50 of 2.44 and 14.27 nM, respectively.
AC1115 also displays potent reversible inhibition of human CTSL activity with IC50 of 0.06 nM, >40-fold selective over other members of the human cysteine cathepsin family.
AC1115 showsno significant inhibition against a panel of 56 human and virus proteases.
AC1115 displays antiviral activity against SARS-CoV-2 VOCs, including WA-1, Alpha, Beta, Delta, Lambda, and Gamma variants with EC50 of 0.28-4.26 μM.
| M.Wt | 412.49 | |
| Formula | C22H28N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Long Mao, et al. Med. 2024 Jan 12;5(1):42-61.e23.
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