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AC1903

Chemical Structure : AC1903

CAS No.: 831234-13-0

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AC1903 (AC-1903)

Catalog No.: PC-60025Not For Human Use, Lab Use Only.

AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM.

Packing Price Stock Quantity
25 mg $218 In stock
50 mg $378 In stock
100 mg $598 In stock
500 mg $958 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM.
AC1903 blocks riluzole-activated TRPC5 whole-cell current, but fails to block carbachol (CCh)-induced TRPC4 and OAG-induced TRPC6 currents, even at high micromolar concentrations.
AC1903 pecifically blocks TRPC5 channel activity in glomeruli of proteinuric rats, suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of FSGS.

Physicochemical Properties

M.Wt 303.365
Formula C19H17N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in DMSO (30.3 mg/mL)
Chemical Name/SMILES

1-benzyl-N-(furan-2-ylmethyl)-1H-benzo[d]imidazol-2-amine

References

1. Zhou Y, et al. Science. 2017 Dec 8;358(6368):1332-1336.

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