Chemical Structure : AC1Q3QWB
CAS No.:
46697-00-1
AC1Q3QWB
(AQB)
Catalog No.: PC-26182Not For Human Use, Lab Use Only.
AC1Q3QWB (ACB) is a selective and efficient inhibitor of HOTAIR-EZH2 interaction with IC50 of 42.47 nM, exhibits potent anti-tumor activity in cancer cells expressing high levels of HOTAIR and EZH2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AC1Q3QWB (ACB) is a selective and efficient inhibitor of HOTAIR-EZH2 interaction with IC50 of 42.47 nM, exhibits potent anti-tumor activity in cancer cells expressing high levels of HOTAIR and EZH2.
ACB selectively blocks HOTAIR-EZH2 interaction and reduces recruitment of PRC2, does not affect EZH2-binding lincRNAs, including GTL2 10, and H19, also does not affect HOTAIR-chromatin interaction.
AQB can effectively up-regulate both mRNA and protein levels of HOTAIR-PRC2 target genes, suppresses Wnt/β-catenin signaling by upregulating APC2 expression.
AQB (50mg/kg) inhibits tumor growth and metastasis in MDA-MB-231 orthotopic breast cancer model, inhibits tumor cell growth and metastasis in vivo.
Low doses of AQB enhance the efficacy of DZNep resulting from more significant expression of HOTAIR-PRC2 target genes.
Physicochemical Properties
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M.Wt
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260.16
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Formula
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C12H15Cl2NO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((5,7-dichloro-2,3-dihydrobenzofuran-2-yl)methyl)propan-2-amine
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References
1. Li Y, et al. Theranostics. 2019 Jun 24;9(16):4608-4623.
2. Shi J, et al. Clin Transl Med. 2020 Jan;10(1):182-198.
3. Tong F, et al. Pharmacol Res. 2023 Jan;187:106606.
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