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AC5 inhibitor C90

Chemical Structure : AC5 inhibitor C90

CAS No.:

AC5 inhibitor C90

Catalog No.: PC-35246Not For Human Use, Lab Use Only.

AC5 inhibitor C90 is a novel potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AC5 inhibitor C90 is a potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes.
    AC5 inhibitor C90 exhibits enhanced AC5 inhibition efficacy and selectivity than PMC6 (IC50=0.15 μM), and 37 times lower than Vidarabine (IC50=1.11 uM).
    AC5 inhibitor C90 reducesd cAMP in response to forskolin in wild type mice by 42%, but no longer reduced cAMP in response to forskolin in mice with disruption of AC5, reduces myocardial infarct size even when administered after coronary artery reperfusion in vivo.

    Physicochemical Properties

    M.Wt
    Formula
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    References

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