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Chemical Structure : AC5 inhibitor C90
Catalog No.: PC-35246Not For Human Use, Lab Use Only.
AC5 inhibitor C90 is a novel potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes.
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AC5 inhibitor C90 is a potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes.
AC5 inhibitor C90 exhibits enhanced AC5 inhibition efficacy and selectivity than PMC6 (IC50=0.15 μM), and 37 times lower than Vidarabine (IC50=1.11 uM).
AC5 inhibitor C90 reducesd cAMP in response to forskolin in wild type mice by 42%, but no longer reduced cAMP in response to forskolin in mice with disruption of AC5, reduces myocardial infarct size even when administered after coronary artery reperfusion in vivo.
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| Appearance | Solid | |
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10 mM in DMSO |
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