AC5 inhibitor C90

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Chemical Structure : AC5 inhibitor C90

Catalog No.: PC-35246Not For Human Use, Lab Use Only.

AC5 inhibitor C90 is a novel potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AC5 inhibitor C90 is a potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes.
AC5 inhibitor C90 exhibits enhanced AC5 inhibition efficacy and selectivity than PMC6 (IC50=0.15 μM), and 37 times lower than Vidarabine (IC50=1.11 uM).
AC5 inhibitor C90 reducesd cAMP in response to forskolin in wild type mice by 42%, but no longer reduced cAMP in response to forskolin in mice with disruption of AC5, reduces myocardial infarct size even when administered after coronary artery reperfusion in vivo.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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