ACA-14 | KRAS inhibitor | Probechem Biochemicals

Chemical Structure : ACA-14

ACA-14 (ACA14)

Catalog No.: PC-20692Not For Human Use, Lab Use Only.

ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.

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Biological Activity

ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.
ACA-14 inhibits signal transduction through the MAPK pathway in cells expressing mutant KRAS and inhibits the growth of pancreatic and colon cancer cells harboring mutant KRAS.

Physicochemical Properties

M.Wt	297.31
Formula	C17H15NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC(NC(C2C(C3=CC=CC=C3)C2)=O)=CC=C1O

References

1. Cynthia V Pagba, et al. ACS Bio Med Chem Au. 2022 Sep 26;2(6):617-626.

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ACA-14 (ACA14)

Biological Activity

Physicochemical Properties

References

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