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Cat. No. Product Name CAS No. Information
PC-73313

MRTX 0902

2654743-22-1 MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK).
PC-72897

JDQ443

2653994-08-0 JDQ443 (NVP-JDQ443) is a potent, mutant-selective, covalent KRAS G12C inhibitor.
PC-36062

ZT-12-037-01

2328073-61-4 ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 of 20.04 nM measured as percentage of NRAS phosphorylation.
PC-35952

MRTX1257

2206736-04-9 MRTX1257 (MRTX-1257, MRTX 1257) is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 0.9 nM.
PC-62695

pan-Ras inhibitor 3144

1835283-94-7 pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor with Kd of 4.7/17/6.6/3.7 uM for KRAS G12D/KRAS wt/HRAS/NRAS respectively.
PC-62496

ARS-1323

1698024-73-5 ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with >10-fold improved potency over the initial ARS-853..
PC-62495

ARS-1630

1698055-86-5 ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound..

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