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Cat. No. Product Name Information
PC-22656

HRS-4642

KRAS G12D inhibitor

HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor with SPR KD of 0.083 nM, >20-fold selective over wild-type KRAS and KRAS G12C.
PC-22626

Glecirasib

KRAS G12C inhibitor

Glecirasib (JAB-21822) is a highly selective, covalent oral KRAS G12C inhibitor, demonstrated promising clinical activity in NSCLC and CRC.
PC-21542

CSC01

KRAS G13D inhibitor

CSC01 (CSC057253844) is a small molecule inhibitor of oncogenic KRAS mutant G13D (KRAS-G13D).
PC-21063

RMC-4998

KRAS G12C inhibitor

RMC-4998 (RM-029) is a tricomplex inhibitor that targets the active state or GTP-bound state of KRAS G12C, selectively inhibits the proliferation of KRASG12C mutant cells with mean IC50 of 0.28 nM.
PC-20878

BI-2493

pan-KRAS inhibitor

BI-2493 is a structural analogue of BI-2865 for in vivo administration, BI-2493 a potent, inactive state selective, non-covalent pan KRAS inhibitor.
PC-20877

BI-2865

pan-KRAS inhibitor

BI-2865 is a potent, inactive state selective, non-covalent pan KRAS inhibitor, binds to the GDP-loaded state of WT, G12C, G12D, G12V and G13D KRAS with high affinity (ITC Kd values,10-40 nM), inactivates common cancer-causing KRAS mutants.
PC-20608

RMC-6291

KRAS G12C inhibitor

RMC-6291 (RMC6291) is a potent, covalent, next-generation, mutant-selective inhibitor of active state KRAS G12C(ON) with IC50 of 0.7 nM (pERK), RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA).
PC-20249

SCH53239

Ras inhibitor

SCH-53239 (SCH53239) is a small molecule inhibitor of Ras nucleotide exchange with IC50 of 0.5 uM, bind competitively with GDP in the nucleotide binding site of the Ras protein.
PC-20037

Fulzerasib

KRAS G12C inhibitor

Fulzerasib (IBI351, IBI-351) is a potent covalent and irreversible inhibitor of KRAS G12C.
PC-49554

RSC-1255

V-ATPase inhibitor

RSC-1255 (KRAS inhibitor 249C, V-ATPase inhibitor) is a Ras-mutant selective cytotoxic agent with nanomolar potency against a spectrum of Ras-mutant cancer cells (A549 (KRASG12S), IC50=73 nM), binds to V-ATPase (Kd=23 nM) and inhibits its activity.
PC-49406

BI-0474

KRAS G12C inhibitor

BI-0474 (BI 0474) is a potent, in vivo active KRAS G12C inhibitor with IC50 of 7.0 nM in GDP-KRAS::SOS1 protein-protein interaction assay.
PC-38706

BC-DXI-32982

DX2-KRAS inhibitor

BC-DXI-32982 is a specific small molecule DX2-KRAS inhibitor that specifically binds to the KRAS-binding region of AIMP2-DX2, inhibits interaction between DX2 and KRAS4B with IC50 of 0.18 uM.

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