| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-73313 |
MRTX 0902
|
2654743-22-1 |
MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK). |
| PC-72897 |
JDQ443
|
2653994-08-0 |
JDQ443 (NVP-JDQ443) is a potent, mutant-selective, covalent KRAS G12C inhibitor. |
| PC-36062 |
ZT-12-037-01
|
2328073-61-4 |
ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 of 20.04 nM measured as percentage of NRAS phosphorylation. |
| PC-35952 |
MRTX1257
|
2206736-04-9 |
MRTX1257 (MRTX-1257, MRTX 1257) is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 0.9 nM. |
| PC-62695 |
pan-Ras inhibitor 3144
|
1835283-94-7 |
pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor with Kd of 4.7/17/6.6/3.7 uM for KRAS G12D/KRAS wt/HRAS/NRAS respectively. |
| PC-62496 |
ARS-1323
|
1698024-73-5 |
ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with >10-fold improved potency over the initial ARS-853.. |
| PC-62495 |
ARS-1630
|
1698055-86-5 |
ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.. |
