| Cat. No. |
Product Name |
Information |
| PC-23832 |
RMC-9805
KRAS G12D inhibitor
|
RMC-9805 is a potent, selective and covalent inhibitor of KRAS G12D with EC50 of 23 nM (AsPC-1, pERK), highly selective for crosslinking RAS G12D(ON). |
| PC-22656 |
HRS-4642
KRAS G12D inhibitor
|
HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor with SPR KD of 0.083 nM, >20-fold selective over wild-type KRAS and KRAS G12C. |
| PC-22626 |
Glecirasib
KRAS G12C inhibitor
|
Glecirasib (JAB-21822) is a highly selective, covalent oral KRAS G12C inhibitor with IC50 of 1.6 nM (SOS1-mediated guanine nucleotide exchange, GDP- KRAS G12C) and IC50 of 7.3 nM in Phospho-ERK inhibition assay in NCI-H358 cells. |
| PC-22125 |
RMC-6236
Ras inhibitor
|
Daraxonrasib (RMC-6236) is a first-in-class broad-spectrum RAS (ON) multi-selective inhibits, inhibits active state of both mutant and wild-type KRAS, NRAS and HRAS variants. |
| PC-21775 |
ADT-007
Ras inhibitor
|
ADT-007 (ADT007) is a potent, specific pan-RAS inhibitor, shows potential to circumvent resistance to mutant-specific KRAS inhibitors and activates antitumor immunity. |
| PC-21542 |
CSC01
KRAS G13D inhibitor
|
CSC01 (CSC057253844) is a small molecule inhibitor of oncogenic KRAS mutant G13D (KRAS-G13D). |
| PC-21263 |
ERAS-5024
KRAS G12D inhibitor
|
ERAS-5024 (ERAS5024) is a potent and selective KRAS G12D inhibitor with IC50 of 0.86 nM in RAS-RAF binding assays, inhibits ERK1/2 phosphorylation (pERK) formation with IC50 of 2.1 nM in AsPC-1 cell-based assays. |
| PC-21063 |
RMC-4998
KRAS G12C inhibitor
|
RMC-4998 (RM-029) is a tricomplex inhibitor that targets the active state or GTP-bound state of KRAS G12C, selectively inhibits the proliferation of KRASG12C mutant cells with mean IC50 of 0.28 nM. |
| PC-20878 |
BI-2493
pan-KRAS inhibitor
|
BI-2493 is a structural analogue of BI-2865 for in vivo administration, BI-2493 a potent, inactive state selective, non-covalent pan KRAS inhibitor. |
| PC-20877 |
BI-2865
pan-KRAS inhibitor
|
BI-2865 is a potent, inactive state selective, non-covalent pan KRAS inhibitor, binds to the GDP-loaded state of WT, G12C, G12D, G12V and G13D KRAS with high affinity (ITC Kd values,10-40 nM), inactivates common cancer-causing KRAS mutants. |
| PC-20608 |
RMC-6291
KRAS G12C inhibitor
|
Elironrasib (RMC-6291) is a potent, covalent, next-generation, mutant-selective inhibitor of active state KRAS G12C(ON) with IC50 of 0.7 nM (pERK), RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). |
| PC-20249 |
SCH53239
Ras inhibitor
|
SCH-53239 (SCH53239) is a small molecule inhibitor of Ras nucleotide exchange with IC50 of 0.5 uM, bind competitively with GDP in the nucleotide binding site of the Ras protein. |
