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Chemical Structure : MK-1084
Catalog No.: PC-22632Not For Human Use, Lab Use Only.
MK-1084 is a potent, orally bioavailable and low-dose KRAS G12C covalent inhibitor with IC50 of 1.2 nM in in vitro guanine nucleotide exchange assay, and 9 nM in cell-based phospho-ERK1/2 assay with H358 cell line.
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MK-1084 is a potent, orally bioavailable and low-dose KRAS G12C covalent inhibitor with IC50 of 1.2 nM in in vitro guanine nucleotide exchange assay, and 9 nM in cell-based phospho-ERK1/2 assay with H358 cell line.
MK-1084 30 mg/kg QD dosing demonstrated excellent efficacy in patient-derived xenograft models, LU2512 and LU2529.
| M.Wt | 637.08 | |
| Formula | C32H31ClF2N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ma X, et al. J Med Chem. 2024 Jun 26. doi: 10.1021/acs.jmedchem.4c00572.
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