| Cat. No. |
Product Name |
Information |
| PC-22632 |
MK-1084
KRAS G12C inhibitor
|
MK-1084 is a potent, orally bioavailable and low-dose KRAS G12C covalent inhibitor with IC50 of 1.2 nM in in vitro guanine nucleotide exchange assay, and 9 nM in cell-based phospho-ERK1/2 assay with H358 cell line. |
| PC-22631 |
LUNA18
KRAS inhibitor
|
LUNA18 (LUNA-18) is a highly potent, 11-mer cyclic peptide inhibitor for the intracellular tough target RAS with IC50 of <2 nM for KRAS G12D-SOS1 PPI, KD of 0.043 nM for KRAS G12C. |
| PC-22562 |
RMC-0331
SOS1 inhibitor
|
RMC-0331 (RMC-023, RM-023) is a potent, selective, and orally bioavailable SOS1 inhibitor, disrupts the critical interaction between KRAS and SOS1, blocks RAS activation. |
| PC-22561 |
HH0043
SOS1 inhibitor
|
HH0043 is a potent, orally bioavailable inhibitor of guanine nucleotide exchange factor (GEF) SOS1 with IC50 of 5.8 nM for KRAS/SOS1 binding inhibition, 54 nM for p-ERK inhibition. |
| PC-22366 |
Deltarasin
PDE6D inhibitor
|
Deltarasin is potent, specfic inhibitor of KRAS-PDEδ (PDE6D) interaction, bind to the prenyl-binding pocket of PDEδ with KD of 38 nM, inhibits oncogenic RAS signalling. |
| PC-22365 |
Deltaflexin3
PDE6D inhibitor
|
Deltaflexin3 is a highly potent, selective and highly soluble inhibitor of the trafficking chaperone PDE6D (PDEδ) with KD value of 6 nM, inhibits PDE6D/K-Ras binding and KRAS mutant cancer cell growth. |
| PC-21798 |
SIJ1772
mutated RAS inhibitor
|
SIJ1772 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 77 and 96 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively. |
| PC-21797 |
SIJ1795
mutated RAS inhibitor
|
SIJ1795 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 82 and 75 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively. |
| PC-21686 |
BBO-8956
KRAS G12C inhibitor
|
BBO-8956 is a highly potent, covalent inhibitor of GTP-KRAS G12C, BBO-8956 is effective against both GDP and GTP-bound KRAS G12C. |
| PC-21640 |
ASP6918
KRAS G12C inhibitor
|
ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells. |
| PC-21604 |
Kobe2602
Ras inhibitor
|
Kobe2602 is a small-molecule Ras inhibitor that display antitumor activity by interfering with Ras·GTP-effector interaction, inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 149 uM. |
| PC-21544 |
KRAS G13D inhibitor 41
KRAS G13D inhibitor
|
KRAS G13D inhibitor 41 is a potent, selective KRAS G13D inhibitor with IC50 of 0.41 nM, 29-fold selective over WT KRAS. |
