| Cat. No. |
Product Name |
Information |
| PC-23830 |
Dual SOS1 and SOS2 binder 1
SOS1/SOS2 binder
|
Dual SOS1 and SOS2 binder 1 is a dual SOS1 and SOS2 binder. |
| PC-23829 |
SOS2 binder 1
SOS2 binder
|
SOS2 binder 1 is a selective quinazoline-based compound that binds to the catalytic site of SOS2 with SPR KD of 4.6 uM, shows no binding to SOS1 up 200 uM. |
| PC-23776 |
INCB159020
KRAS G12D inhibitor
|
INCB159020 is a potent, selective KRAS G12D inhibitor with SPR binding Kd of 22 nM, IC50 of 33 nM in HTRF pERK cell assays. |
| PC-22872 |
KRAS G12C inhibitor 143D
KRAS G12C inhibitor
|
143D is a highly potent and selective, BBB-permeable KRAS G12C inhibitor, inhibits the binding of KRASG12C and SOS1 with IC50 of 21.1 nM. |
| PC-22827 |
LY3499446 mesylate
KRAS G12C inhibitor
|
LY3499446 mesylate is a potent, selective inhibitor of KRAS G12C. |
| PC-22826 |
LY3499446
KRAS G12C inhibitor
|
LY3499446 is a potent, selective inhibitor of KRAS G12C. |
| PC-22825 |
VT204
KRAS G12C inhibitor
|
VT204 is a small molecule inhibitor of KRAS G12C, effectively suppresses cell proliferation in NCI-H358 cells at 8 uM. |
| PC-22804 |
RGT-018
SOS1 inhibitor
|
RGT-018 is a potent and selective SOS1 inhibitor, blocks interaction of KRAS:SOS1 with single digit nM potency and is highly selective against SOS2. |
| PC-22631 |
LUNA18
KRAS inhibitor
|
LUNA18 (LUNA-18) is a highly potent, 11-mer cyclic peptide inhibitor for the intracellular tough target RAS with IC50 of <2 nM for KRAS G12D-SOS1 PPI, KD of 0.043 nM for KRAS G12C. |
| PC-22562 |
RMC-0331
SOS1 inhibitor
|
RMC-0331 (RMC-023, RM-023) is a potent, selective, and orally bioavailable SOS1 inhibitor, disrupts the critical interaction between KRAS and SOS1, blocks RAS activation. |
| PC-22561 |
HH0043
SOS1 inhibitor
|
HH0043 is a potent, orally bioavailable inhibitor of guanine nucleotide exchange factor (GEF) SOS1 with IC50 of 5.8 nM for KRAS/SOS1 binding inhibition, 54 nM for p-ERK inhibition. |
| PC-22366 |
Deltarasin
PDE6D inhibitor
|
Deltarasin is potent, specfic inhibitor of KRAS-PDEδ (PDE6D) interaction, bind to the prenyl-binding pocket of PDEδ with KD of 38 nM, inhibits oncogenic RAS signalling. |
