RGT-018 (RGT018)

Chemical Structure : RGT-018

CAS No.: 2794934-49-7

Catalog No.: PC-22804Not For Human Use, Lab Use Only.

RGT-018 (RGT018) is a potent and selective SOS1 inhibitor, blocks interaction of KRAS:SOS1 with single digit nM potency and is highly selective against SOS2.

Packing	Price	Stock
5 mg	$148	In stock
10 mg	$218	In stock
25 mg	$358	In stock
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Biological Activity

RGT-018 (RGT018) is a potent and selective SOS1 inhibitor, blocks interaction of KRAS:SOS1 with single digit nM potency and is highly selective against SOS2.

Physicochemical Properties

M.Wt	535.53
Formula	C27H24F3N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-(4-((1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2-methyl-6-morpholino-7-oxo-6,7-dihydropyrido[4,3-d]pyrimidin-8-yl)picolinonitrile

References

1. Xiao F, et al. Mol Cancer Ther. 2024 Aug 1. doi: 10.1158/1535-7163.MCT-24-0049.

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RGT-018 (RGT018)

Biological Activity

Physicochemical Properties

References

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