| Cat. No. |
Product Name |
Information |
| PC-24666 |
AZD0022
KRAS G12D inhibitor
|
AZD0022 is a potent, selective and orally bioavailable inhibitor of KRAS G12D. |
| PC-24581 |
K-RAS4B inhibitor Cmpd2
KRAS4b inhibitor
|
KRAS4B inhibitor Cmpd2 is a specific inhibitor of K-RAS4B, inhibtis the KRAS activation of BRAF with IC50 of 0.8 uM in coupled assays, and BLI Kd of <1 uM prenylated K-RAS4B in the presence of PS. |
| PC-24580 |
KRAS4b inhibitor Compound 3
KRAS4b inhibitor
|
KRAS4b inhibitor Compound 3 is a specific small molecule covalent modifier of canonical RAS isoform KRAS4b CaaX-box cysteine (C185), prevents its posttranslational processing and subsequent membrane attachment. |
| PC-24579 |
KRAS4b inhibitor Compound 2
KRAS4b inhibitor
|
SMDC994566 (KRAS4b inhibitor Compound 2) is a specific small molecule covalent modifier of canonical RAS isoform KRAS4b CaaX-box cysteine (C185), decreases proliferation and KRAS protein level in KRAS-dependent MEF cells. |
| PC-24267 |
SOF-436
Ras inhibitor
|
SOF-436 is a small molecule covalent KRAS inhibitor with IC50 of 60 uM in nucleotide exchange assays, inhibits KRAS nucleotide exchange by guanine exchange factor SOS1 and the binding of KRAS to effector protein RAF. |
| PC-24256 |
(RS)-G12Di-1
KRAS-G12D inhibitor
|
(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D. |
| PC-24185 |
Sosimerasib
Ras inhibitor
|
Sosimerasib is a potent, selective inhibitor of KRAS. |
| PC-23931 |
ISM061-022
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor with IC50 values in the micromolar range, shows selectivity toward certain KRAS mutants. |
| PC-23930 |
ISM061-018-2
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor, exhibits substantial binding affinity to KRAS-G12D with SPR Kd of 1.4 uM, exhibits broad activity across KRAS mutants. |
| PC-23830 |
Dual SOS1 and SOS2 binder 1
SOS1/SOS2 binder
|
Dual SOS1 and SOS2 binder 1 is a dual SOS1 and SOS2 binder. |
| PC-23829 |
SOS2 binder 1
SOS2 binder
|
SOS2 binder 1 is a selective quinazoline-based compound that binds to the catalytic site of SOS2 with SPR KD of 4.6 uM, shows no binding to SOS1 up 200 uM. |
| PC-23776 |
INCB159020
KRAS G12D inhibitor
|
INCB159020 is a potent, selective KRAS G12D inhibitor with SPR binding Kd of 22 nM, IC50 of 33 nM in HTRF pERK cell assays. |
