| Cat. No. |
Product Name |
Information |
| PC-62495 |
ARS-1630
|
ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.. |
| PC-62494 |
ARS-1620
KRAS G12C inhibitor
|
ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with an observed rate of 1,100±200 M-1S-1, shows >10-fold improved potency over the initial ARS-853. |
| PC-62490 |
NSC 658497
SOS1 inhibitor
|
NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. |
| PC-62207 |
SCH 54292
Ras-GEF inhibitor
|
SCH 54292 is a potent Ras-GEF interaction inhibitor with IC50 of 0.7 uM. |
| PC-61154 |
Deltasonamide 2
|
Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM. |
| PC-61153 |
Deltasonamide 1
PDE6δ/KRas inhibitor
|
Deltasonamide 1 is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM. |
| PC-61152 |
Deltazinone 1
|
Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM. |
| PC-60886 |
UC-857993
SOS1-Ras inhibitor
|
UC-857993 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction. |
| PC-60885 |
UC-773587
SOS1-Ras inhibitor
|
UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction. |
| PC-70154 |
ML-162
|
ML-162 (ML162) is a small-molecule probe that selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM. |
| PC-45721 |
ML-098
Ras activator
|
ML-098 (CID-7345532) is a small molecule pan activator families of Ras-related GTPases (EC50=77-588 nM for Rab7, Rab-2A, Cdc42, Rac1). |
| PC-45673 |
ARS-853
KRAS G12C inhibitor
|
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM. |
