| Cat. No. |
Product Name |
Information |
| PC-63506 |
CMC2.24
Ras inhibitor
|
CMC2.24 (TRB-N0224) is a novel tricarbonylmethane agent that inhibits the Ras-RAF-MEK-ERK pathway, inhibits Ras activation in pancreatic cancer both in vitro and in vivo. |
| PC-62695 |
pan-Ras inhibitor 3144
Ras inhibitor
|
pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor with Kd of 4.7/17/6.6/3.7 uM for KRAS G12D/KRAS wt/HRAS/NRAS respectively. |
| PC-62496 |
ARS-1323
KRAS G12C inhibitor
|
ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with >10-fold improved potency over the initial ARS-853.. |
| PC-62495 |
ARS-1630
|
ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.. |
| PC-62494 |
ARS-1620
KRAS G12C inhibitor
|
ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with an observed rate of 1,100±200 M-1S-1, shows >10-fold improved potency over the initial ARS-853. |
| PC-62490 |
NSC 658497
SOS1 inhibitor
|
NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. |
| PC-62207 |
SCH 54292
Ras-GEF inhibitor
|
SCH 54292 is a potent Ras-GEF interaction inhibitor with IC50 of 0.7 uM. |
| PC-61995 |
PDEδ-IN-99
PDE6D-RAS inhibitor
|
PDEδ-IN-99 is a novel potent K-Ras-PDEδ inhibitor that binds to the farnesyl binding pocket of PDEδ (PDE6D) with Kd of 8 nM. |
| PC-61154 |
Deltasonamide 2
|
Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM. |
| PC-61153 |
Deltasonamide 1
PDE6D-RAS inhibitor
|
Deltasonamide 1 is a specific small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM. |
| PC-61152 |
Deltazinone 1
PDE6D-RAS inhibitor
|
Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM. |
| PC-60886 |
UC-857993
SOS1-Ras inhibitor
|
UC-857993 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction. |
