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Cat. No. Product Name Information
PC-72214

ABD957

ABHD17 inhibitor

ABD957 (ABD-957) is a potent, selective covalent inhibitor of the ABHD17 family of depalmitoylases, impairs N-Ras depalmitoylation in human AML cells.
PC-72019

Rasarfin

Ras-ARF6 inhibitor

Rasarfin is a novel dual Ras and ARF6 inhibitor, selectively inhibits small G proteins Ras and ARF6 with IC50 of 7 and 0.7 uM.
PC-38332

Ras binder compound 3

Ras inhibitor

Ras binder compound 3 is a switch-II binding ligand which binds Ras GDP and GTP states, inhibits PI3K activation in vitro.
PC-38331

Ras binder 2C07

Ras inhibitor

Ras binder 2C07 is a switch-II binding ligand which binds Ras GDP and GTP states.
PC-38330

Ral inhibitor 1

RalB inhibitor

Ral inhibitor 1 is a covalent inhibitor of RalB (Ras-like GTPase) activation, inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral GTPase, selectively inhibits Ral over Ras.
PC-38329

KAL-21404358

KRAS G12D inhibitor

KAL-21404358 (KAL21404358) is a small-molecule, allosteric inhibitor of K-Ras(G12D), binds to K-Ras(G12D) P110 site with KD of 88 uM in MST assay.
PC-38328

KRpep-2d

KRAS G12D inhibitor

KRpep-2d (Ac-RRCPLYISYDPVCRR-NH2) is a potent, selective, cell-membrane permeable, cyclic peptide inhibitor of K-Ras(G12D) with IC50 of 1.6 nM, >10-fold selectivity over WT and G12C KRas.
PC-38327

K-Ras G12D inhibitor KS-58

KRAS G12D inhibitor

K-Ras G12D inhibitor KS-58 is the first K-Ras(G12D) selective, bicyclic peptide inhibitor with binding Ki of 22 nM.
PC-38298

ML210

GPX4 inhibitor

ML210 (ML-210, CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS.
PC-38296

BI-3406

SOS1 inhibitor

BI-3406 (BI 3406) is a highly potent and selective SOS1-KRAS interaction inhibitor with IC50 of 5 nM, binds to the catalytic domain of SOS1 with Kd of 9.7 nM.
PC-38293

VUBI1

SOS1 activator

VUBI1 (SOS1 agonist 1) is a potent activator of SOS1 which modulates the KRAS pathway, binds directly to SOS1 (Kd=44 nM).
PC-38152

IODVA1

Rac inhibitor

IODVA1 is a small molecule with cellular inhibitory activity against several transformed cell lines including Ras-driven cells, targets Rac activation and signaling instead of Ras.

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