| Cat. No. |
Product Name |
Information |
| PC-72332 |
BI-2852
KRAS inhibitor
|
BI-2852 (BI 2852) is a potent pan-Ras inhibitor, targets GTP-bound KRAS, binds to KRASG12D with a KD of 740 nM (ITC), inhibits GTP-KRAS G12D binding to effectors like SOS1, CRAF and PI3Kα with an IC50 of 490, 770 and 500 nM. |
| PC-72331 |
MRTX1133
KRAS G12D inhibitor
|
MRTX-1133 (MRTX1133) is a potent, selective and noncovalent inhibitor KRAS G12D with SPR Kd of 0.2 nM, AlphaLISA IC50 of 5 nM. |
| PC-72314 |
KRAS G12C Pipetide LVVVGACGVGK
|
KRAS G12C Pipetide (LVVVGACGVGK) is a KRas4B G12C allele-specific N-terminal mutant tryptic peptide. |
| PC-72313 |
LY-3537982
KRAS-G12C inhibitor
|
LY-3537982 (LY3537982) is a highly selective and potent KRAS-G12C inhibitor, selectively inhibits growth of KRAS G12C mutant cells (IC50=1-60 nM). |
| PC-72227 |
MRTX849
KRAS G12C inhibitor
|
MRTX849 (Adagrasib, MRTX-849) is a potent, selective, and covalent KRAS G12C inhibitor, inhibits KRAS-dependent signaling. |
| PC-72222 |
Chelidonine
STK19 inhibitor
|
Chelidonine (Stylophorin, (+)-Chelidonine) is a potent, selective, ATP-competitive inhibitor of STK19 kinase activity, inhibits STK19-mediated NRAS S89 phosphorylation with IC50 of 125 nM, inhibits NRAS-mediated signaling. |
| PC-72214 |
ABD957
ABHD17 inhibitor
|
ABD957 (ABD-957) is a potent, selective covalent inhibitor of the ABHD17 family of depalmitoylases, impairs N-Ras depalmitoylation in human AML cells. |
| PC-72019 |
Rasarfin
Ras-ARF6 inhibitor
|
Rasarfin is a novel dual Ras and ARF6 inhibitor, selectively inhibits small G proteins Ras and ARF6 with IC50 of 7 and 0.7 uM. |
| PC-38332 |
Ras binder compound 3
Ras inhibitor
|
Ras binder compound 3 is a switch-II binding ligand which binds Ras GDP and GTP states, inhibits PI3K activation in vitro. |
| PC-38331 |
Ras binder 2C07
Ras inhibitor
|
Ras binder 2C07 is a switch-II binding ligand which binds Ras GDP and GTP states. |
| PC-38330 |
Ral inhibitor 1
RalB inhibitor
|
Ral inhibitor 1 is a covalent inhibitor of RalB (Ras-like GTPase) activation, inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral GTPase, selectively inhibits Ral over Ras. |
| PC-38329 |
KAL-21404358
KRAS G12D inhibitor
|
KAL-21404358 (KAL21404358) is a small-molecule, allosteric inhibitor of K-Ras(G12D), binds to K-Ras(G12D) P110 site with KD of 88 uM in MST assay. |
