| Cat. No. |
Product Name |
Information |
| PC-72227 |
MRTX849
KRAS G12C inhibitor
|
MRTX849 (Adagrasib, MRTX-849) is a potent, selective, and covalent KRAS G12C inhibitor, inhibits KRAS-dependent signaling. |
| PC-72222 |
Chelidonine
STK19 inhibitor
|
Chelidonine (Stylophorin, (+)-Chelidonine) is a potent, selective, ATP-competitive inhibitor of STK19 kinase activity, inhibits STK19-mediated NRAS S89 phosphorylation with IC50 of 125 nM, inhibits NRAS-mediated signaling. |
| PC-72214 |
ABD957
ABHD17 inhibitor
|
ABD957 (ABD-957) is a potent, selective covalent inhibitor of the ABHD17 family of depalmitoylases, impairs N-Ras depalmitoylation in human AML cells. |
| PC-72019 |
Rasarfin
Ras-ARF6 inhibitor
|
Rasarfin is a novel dual Ras and ARF6 inhibitor, selectively inhibits small G proteins Ras and ARF6 with IC50 of 7 and 0.7 uM. |
| PC-38332 |
Ras binder compound 3
Ras inhibitor
|
Ras binder compound 3 is a switch-II binding ligand which binds Ras GDP and GTP states, inhibits PI3K activation in vitro. |
| PC-38331 |
Ras binder 2C07
Ras inhibitor
|
Ras binder 2C07 is a switch-II binding ligand which binds Ras GDP and GTP states. |
| PC-38330 |
Ral inhibitor 1
RalB inhibitor
|
Ral inhibitor 1 is a covalent inhibitor of RalB (Ras-like GTPase) activation, inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral GTPase, selectively inhibits Ral over Ras. |
| PC-38329 |
KAL-21404358
KRAS G12D inhibitor
|
KAL-21404358 (KAL21404358) is a small-molecule, allosteric inhibitor of K-Ras(G12D), binds to K-Ras(G12D) P110 site with KD of 88 uM in MST assay. |
| PC-38328 |
KRpep-2d
KRAS G12D inhibitor
|
KRpep-2d (Ac-RRCPLYISYDPVCRR-NH2) is a potent, selective, cell-membrane permeable, cyclic peptide inhibitor of K-Ras(G12D) with IC50 of 1.6 nM, >10-fold selectivity over WT and G12C KRas. |
| PC-38327 |
K-Ras G12D inhibitor KS-58
KRAS G12D inhibitor
|
K-Ras G12D inhibitor KS-58 is the first K-Ras(G12D) selective, bicyclic peptide inhibitor with binding Ki of 22 nM. |
| PC-38298 |
ML210
GPX4 inhibitor
|
ML210 (ML-210, CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS. |
| PC-38296 |
BI-3406
SOS1 inhibitor
|
BI-3406 (BI 3406) is a highly potent and selective SOS1-KRAS interaction inhibitor with IC50 of 5 nM, binds to the catalytic domain of SOS1 with Kd of 9.7 nM. |
