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APS6-45

Chemical Structure : APS6-45

CAS No.: 2188236-41-9

APS6-45 (RAS/MAPK inhibitor)

Catalog No.: PC-38595Not For Human Use, Lab Use Only.

APS6-45 is a small molecule Tumor-Calibrated Inhibitor (TCI) by reducing activity towards BRAF and Lk6/MKNK, inhibits RAS/MAPK signaling.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

APS6-45 is a small molecule Tumor-Calibrated Inhibitor (TCI) by reducing activity towards BRAF and Lk6/MKNK, inhibits RAS/MAPK signaling.
APS6-45 strongly inhibits Ret-mediated transformation with minimal whole animal toxicity.
APS6-45 strongly inhibited RAS pathway signaling in human MTC cell lines TT and MZ-CRC-1.
APS6-45 inhibited growth of established TT tumors in the subcutaneous tissue of xenografted nude mice far more potently than sorafenib or cabozantinib.

Physicochemical Properties

M.Wt 548.39
Formula C23H16F8N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[4-[[[[2-Fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide

References

1. Sonoshita M, et, al. Nat Chem Biol. 2018 Mar;14(3):291-298.

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