| Cat. No. |
Product Name |
Information |
| PC-24662 |
AMG410
KRAS inhibitor
|
AMG410 is a potent, non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D,> 100-fold selectivity against both HRAS and NRAS. |
| PC-24200 |
Zoldonrasib
KRAS inhibitor
|
Zoldonrasib (RMC-9805) is a potent, selective covalent peptide-linked macrocyclic dipeptidic inhibitor of KRAS G12D. |
| PC-24126 |
D3S-001
KRAS G12C inhibitor
|
Elisrasib (D3S-001) is a potent, selective, CNS-penetrable, covalent inhibitor of GDP-bound KRAS G12C inhibitor, decreases cellular active KRAS proteins in a dose-dependent manner (IC50=0.6 nM) in NCI-H358 cells. |
| PC-23832 |
RMC-9805
KRAS G12D inhibitor
|
Zoldonrasib (RMC-9805) is a potent, selective and covalent inhibitor of KRAS G12D with EC50 of 23 nM (AsPC-1, pERK), highly selective for crosslinking RAS G12D(ON). |
| PC-23212 |
ADT-1004
Ras inhibitor
|
ADT-1004 is an orally bioavailable prodrug of ADT-007, potent, selective pan-RAS inhibitor, selectively inhibits PDAC cells with mutant KRAS, does not impact the growth of tumors from RAS WT PDAC cells. |
| PC-22982 |
Sotorasib
KRAS G12C inhibitor
|
Sotorasib (AMG-510) is a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM. |
| PC-22656 |
HRS-4642
KRAS G12D inhibitor
|
HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor with SPR KD of 0.083 nM, >20-fold selective over wild-type KRAS and KRAS G12C. |
| PC-22632 |
MK-1084
KRAS G12C inhibitor
|
Calderasib (MK-1084) is a potent, orally bioavailable and low-dose KRAS G12C covalent inhibitor with IC50 of 1.2 nM in in vitro guanine nucleotide exchange assay, and 9 nM in cell-based phospho-ERK1/2 assay with H358 cell line. |
| PC-22626 |
Glecirasib
KRAS G12C inhibitor
|
Glecirasib (JAB-21822) is a highly selective, covalent oral KRAS G12C inhibitor with IC50 of 1.6 nM (SOS1-mediated guanine nucleotide exchange, GDP- KRAS G12C) and IC50 of 7.3 nM in Phospho-ERK inhibition assay in NCI-H358 cells. |
| PC-22125 |
RMC-6236
Ras inhibitor
|
Daraxonrasib (RMC-6236) is a first-in-class broad-spectrum RAS (ON) multi-selective inhibits, inhibits active state of both mutant and wild-type KRAS, NRAS and HRAS variants. |
| PC-22123 |
BBO-8520
KRAS G12C inhibitor
|
BBO-8520 is a potent, selective and covalent inhibitor of KRAS G12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding. |
| PC-22112 |
RMC-7977
Ras inhibitor
|
RMC-7977 (RMC7977) is a potent, highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with Kd of 116 nM, 94.7 nM and 101 nM respectively, KRAS G12V Kd of 85 nM. |
