| Cat. No. |
Product Name |
Information |
| PC-49406 |
BI-0474
KRAS G12C inhibitor
|
BI-0474 (BI 0474) is a potent, in vivo active KRAS G12C inhibitor with IC50 of 7.0 nM in GDP-KRAS::SOS1 protein-protein interaction assay. |
| PC-49153 |
G12Si-5
K-Ras(G12S) inhibitor
|
G12Si-5 is a specific small molecule that covalently targets K-Ras(G12S) mutation, suppresses K-Ras(G12S) signaling, preferentially inhibits the growth of the K-Ras(G12S)-transduced cells with IC50 of 2.4 uM. |
| PC-38706 |
BC-DXI-32982
DX2-KRAS inhibitor
|
BC-DXI-32982 is a specific small molecule DX2-KRAS inhibitor that specifically binds to the KRAS-binding region of AIMP2-DX2, inhibits interaction between DX2 and KRAS4B with IC50 of 0.18 uM. |
| PC-38595 |
APS6-45
RAS/MAPK inhibitor
|
APS6-45 is a small molecule Tumor-Calibrated Inhibitor (TCI) by reducing activity towards BRAF and Lk6/MKNK, inhibits RAS/MAPK signaling. |
| PC-38549 |
AZD4625
KRAS G12C inhibitor
|
AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM. |
| PC-38456 |
Kobe0065
Ras inhibitor
|
Kobe0065 is a small-molecule Ras inhibitor, competitively inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 46 uM. |
| PC-38438 |
MRTX-EX185
KRAS G12D inhibitor
|
MRTX-EX185 (EX185) is a novel potent small-molecule inhibitor of KRAS mutants, exhibits target engagement against KRAS (G12D) with IC50 of 90 nM, binds to GDP-loaded KRAS and KRAS(G12D), as well as the active GNP state. |
| PC-73419 |
Garsorasib
KRas G12C inhibitor
|
Garsorasib (D-1553) is a potent, selective, orally bioavailable and covalent KRas-G12C inhibitor with IC50 of 10 nM, exhibits potent anti-tumor activity in a broad spectrum of tumor cell lines. |
| PC-73367 |
DW0254
PDE6D-RAS inhibitor
|
DW0254 (DW-0254) is a small molecules capable of inhibiting RAS-related C3 botulinum toxin substrate (RAC) small GTPase activation in ALL cell lines, directly binds to the hydrophobic pocket of PDE6D (Kd=436 nM, ITC), a RAS chaperone protein. |
| PC-73323 |
GDC-6036
KRAS G12C inhibitor
|
GDC-6036 (Divarasib, RG6330) is a potent, selective, covalent and orally available KRAS G12C inhibitor with HTRF IC50 of 2.9 pM. |
| PC-73313 |
MRTX0902
SOS1 inhibitor
|
MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK). |
| PC-73069 |
Sotorasib racemate
KRAS G12C inhibitor
|
Sotorasib (AMG510) racemate is an orally active racemate of Sotorasib (AMG510), a potent, selective, covalent KRAS G12C inhibitor. |
