RMC-9805 | KRAS G12D inhibitor | Probechem Biochemicals

Chemical Structure : RMC-9805

CAS No.: 2922732-54-3

RMC-9805 (RMC9805)

Catalog No.: PC-23832Not For Human Use, Lab Use Only.

RMC-9805 is a potent, selective and covalent inhibitor of KRAS G12D with EC50 of 23 nM (AsPC-1, pERK), highly selective for crosslinking RAS G12D(ON).

Packing	Price	Stock
1 mg	$158	In stock
5 mg	$298	In stock
10 mg	$488	In stock
25 mg	$788	In stock
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Biological Activity

RMC-9805 is a potent, selective and covalent inhibitor of KRAS G12D with EC50 of 23 nM (AsPC-1, pERK), highly selective for crosslinking RAS G12D(ON).
RMC-9805 modulates RAS pathway signaling and induces apoptosis in KRASG12D xenograft tumors in vivo, causes regressions of KRASG12D xenograft models at well-tolerated doses in vivo.
RMC-9805 monotherapy elicited tumor regressions in most preclinical PDAC and NSCLC cancer models harboring KRASG12D.
RMC-9805 also synergized with anti-PD1 therapy in KRASG12D tumors in immune-competent animal models by shaping a favorable tumor immune microenvironment through cytokine modulation.

Physicochemical Properties

M.Wt	1168.44
Formula	C63H88F3N11O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-Cyclopentyl-2-((S)-7-((2R,3R)-3-cyclopropyl-1-methylaziridine-2-carbonyl)-2,7-diazaspiro[4.4]nonan-2-yl)-N-((22S,63S,4S)-12-(5-(4-cyclopropylpiperazin-1-yl)-2-((S)-1-methoxyethyl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-11-(2,2,2-trifluoroethyl)-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-morpholina-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)acetamide

References

1. Lingyan Jiang, et al. Cancer Res (2023) 83 (7_Supplement): 526.

RMC-9805 (RMC9805)

Biological Activity

Physicochemical Properties

References

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