Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Sotorasib
CAS No.: 2252403-56-6
Catalog No.: PC-73069Not For Human Use, Lab Use Only.
Sotorasib (AMG510) is a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $698 | In stock | |
| 250 mg | $1280 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Sotorasib (AMG510) is a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM.
AMG510 showed great promise in the treatment of KRAS p.G12C-mutant tumors both pre-clinically and clinically.
Treatment with AMG 510 led to the regression of KRASG12C tumours and improved the anti-tumour efficacy of chemotherapy and targeted agents.
In immune-competent mice, treatment with AMG 510 resulted in a pro-inflammatory tumour microenvironment and produced durable cures alone as well as in combination with immune-checkpoint inhibitors.
| M.Wt | 560.61 | |
| Formula | C30H30F2N6O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one |
|
1. Lanman BA, et al. J Med Chem. 2020 Jan 9;63(1):52-65.
2. Canon J, et al. Nature. 2019 Nov;575(7781):217-223.
3. Ryan MB, et al. Clin Cancer Res. 2020 Apr 1;26(7):1633-1643.
4. McCormick F. Cancer Cell. 2020 Jan 13;37(1):3-4.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
