| Cat. No. |
Product Name |
Information |
| PC-20553 |
Igf2bp1 inhibitor 7773
Igf2bp1 inhibitor
|
Igf2bp1 inhibitor 7773 is a specific small molecule inhibitor of Igf2bp1, binds to RNA binding domains of Igf2bp1, inhibits Igf2bp1 binding of Kras 6 RNA with IC50 of 30 uM. |
| PC-20251 |
Lonafranib
Ras inhibitor
|
Lonafranib (SCH 66336) is a potent, selective and orally active farnesyl protein transferase (FPT) inhibitor with IC50 of 1.9 nM, 5.2 nM and 2.8 nM for H-ras, K-ras-4B and N-ras, respectively. |
| PC-20249 |
SCH53239
Ras inhibitor
|
SCH-53239 (SCH53239) is a small molecule inhibitor of Ras nucleotide exchange with IC50 of 0.5 uM, bind competitively with GDP in the nucleotide binding site of the Ras protein. |
| PC-20037 |
Fulzerasib
Ras inhibitor
|
Fulzerasib is a potent selective inhibitor of KRAS gene mutation. |
| PC-49153 |
G12Si-5
K-Ras(G12S) inhibitor
|
G12Si-5 is a specific small molecule that covalently target K-Ras(G12S) mutation, suppresses K-Ras(G12S) signaling, preferentially inhibits the growth of the K-Ras(G12S)-transduced cells with IC50 of 2.4 uM. |
| PC-38706 |
BC-DXI-32982
DX2-KRAS inhibitor
|
BC-DXI-32982 is a specific small molecule DX2-KRAS inhibitor that specifically binds to the KRAS-binding region of AIMP2-DX2, inhibits interaction between DX2 and KRAS4B with IC50 of 0.18 uM. |
| PC-38595 |
APS6-45
RAS/MAPK inhibitor
|
APS6-45 is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity. |
| PC-38456 |
Kobe0065
Ras inhibitor
|
Kobe0065 is a small-molecule Ras inhibitor, competitively inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 46 uM. |
| PC-72832 |
NSC290956
Kras inhibitor
|
NSC290956 is a small molecule inhibitor of KRas with Kd of 21.3 uM. |
| PC-72503 |
K-tetracosapeptide
KARATE inhibitor
|
K-tetracosapeptide (K-TC) is a peptide of 24 amino acids corresponding to the helix a5 in KRAS4B, potent inhibitor of KARATE (KRAS4B-RHOA-mTORC2 Ensemble), specifically targets the KRAS4B-RHOA interaction. |
| PC-72502 |
TAT-K-tetracosapeptide
KARATE inhibitor
|
TAT-K-tetracosapeptide is K-tetracosapeptide fused to a cell-permeable TAT peptide, K-tetracosapeptide (K-TC) is a peptide of 24 amino acids corresponding to the helix a5 in KRAS4B, potent inhibitor of KARATE. |
| PC-72332 |
BI-2852
KRAS inhibitor
|
BI-2852 (BI 2852) is a potent pan-Ras inhibitor, targets GTP-bound KRAS, binds to KRASG12D with a KD of 740 nM (ITC), inhibits GTP-KRAS G12D binding to effectors like SOS1, CRAF and PI3Kα with an IC50 of 490, 770 and 500 nM. |
