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RasGRP3 ligand 96

Chemical Structure : RasGRP3 ligand 96

CAS No.: 2229068-13-5

RasGRP3 ligand 96

Catalog No.: PC-35300Not For Human Use, Lab Use Only.

RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, showed 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, shows 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively.
RasGRP3 ligand 96 induces Ras activation, a downstream response to RasGRP stimulation, with 8-29 fold selectivity relative to PKCδ S299 phosphorylation in intact cells.

Physicochemical Properties

M.Wt 371.433
Formula C21H25NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-(2-(Hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl pivalate

References

1. Ann J, et al. J Med Chem. 2018 Jul 3. doi: 10.1021/acs.jmedchem.8b00661.

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