| Cat. No. |
Product Name |
Information |
| PC-23832 |
RMC-9805
KRAS G12D inhibitor
|
RMC-9805 is a potent, selective and covalent inhibitor of KRAS G12D with EC50 of 23 nM (AsPC-1, pERK), highly selective for crosslinking RAS G12D(ON). |
| PC-23830 |
Dual SOS1 and SOS2 binder 1
SOS1/SOS2 binder
|
Dual SOS1 and SOS2 binder 1 is a dual SOS1 and SOS2 binder. |
| PC-23829 |
SOS2 binder 1
SOS2 binder
|
SOS2 binder 1 is a selective quinazoline-based compound that binds to the catalytic site of SOS2 with SPR KD of 4.6 uM, shows no binding to SOS1 up 200 uM. |
| PC-23776 |
INCB159020
KRAS G12D inhibitor
|
INCB159020 is a potent, selective KRAS G12D inhibitor with SPR binding Kd of 22 nM, IC50 of 33 nM in HTRF pERK cell assays. |
| PC-23212 |
ADT-1004
Ras inhibitor
|
ADT-1004 is an orally bioavailable prodrug of ADT-007, potent, selective pan-RAS inhibitor, selectively inhibits PDAC cells with mutant KRAS, does not impact the growth of tumors from RAS WT PDAC cells. |
| PC-22982 |
Sotorasib (AMG-510)
KRAS G12C inhibitor
|
Sotorasib (AMG510) racemate s a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM. |
| PC-22872 |
KRAS G12C inhibitor 143D
KRAS G12C inhibitor
|
143D is a highly potent and selective, BBB-permeable KRAS G12C inhibitor, inhibits the binding of KRASG12C and SOS1 with IC50 of 21.1 nM. |
| PC-22827 |
LY3499446 mesylate
KRAS G12C inhibitor
|
LY3499446 mesylate is a potent, selective inhibitor of KRAS G12C. |
| PC-22826 |
LY3499446
KRAS G12C inhibitor
|
LY3499446 is a potent, selective inhibitor of KRAS G12C. |
| PC-22825 |
VT204
KRAS G12C inhibitor
|
VT204 is a small molecule inhibitor of KRAS G12C, effectively suppresses cell proliferation in NCI-H358 cells at 8 uM. |
| PC-22804 |
RGT-018
SOS1 inhibitor
|
RGT-018 is a potent and selective SOS1 inhibitor, blocks interaction of KRAS:SOS1 with single digit nM potency and is highly selective against SOS2. |
| PC-22632 |
MK-1084
KRAS G12C inhibitor
|
MK-1084 is a potent, orally bioavailable and low-dose KRAS G12C covalent inhibitor with IC50 of 1.2 nM in in vitro guanine nucleotide exchange assay, and 9 nM in cell-based phospho-ERK1/2 assay with H358 cell line. |
