| Cat. No. |
Product Name |
Information |
| PC-60886 |
UC-857993
SOS1-Ras inhibitor
|
UC-857993 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction. |
| PC-60885 |
UC-773587
SOS1-Ras inhibitor
|
UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction. |
| PC-70154 |
ML162
GPX4 inhibitor
|
ML162 (ML-162) is a small-molecule, covalent glutathione peroxidase 4 (GPX4) inhibitor, selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM. |
| PC-45721 |
ML-098
Ras activator
|
ML-098 (CID-7345532) is a small molecule pan activator families of Ras-related GTPases (EC50=77-588 nM for Rab7, Rab-2A, Cdc42, Rac1). |
| PC-45673 |
ARS-853
KRAS G12C inhibitor
|
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM. |
| PC-45476 |
K-Ras G12C-IN-1
KRAS G12C inhibitor
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| PC-24581 |
K-RAS4B inhibitor Cmpd2
KRAS4b inhibitor
|
KRAS4B inhibitor Cmpd2 is a specific inhibitor of K-RAS4B, inhibtis the KRAS activation of BRAF with IC50 of 0.8 uM in coupled assays, and BLI Kd of <1 uM prenylated K-RAS4B in the presence of PS. |
| PC-24580 |
KRAS4b inhibitor Compound 3
KRAS4b inhibitor
|
KRAS4b inhibitor Compound 3 is a specific small molecule covalent modifier of canonical RAS isoform KRAS4b CaaX-box cysteine (C185), prevents its posttranslational processing and subsequent membrane attachment. |
| PC-24579 |
KRAS4b inhibitor Compound 2
KRAS4b inhibitor
|
SMDC994566 (KRAS4b inhibitor Compound 2) is a specific small molecule covalent modifier of canonical RAS isoform KRAS4b CaaX-box cysteine (C185), decreases proliferation and KRAS protein level in KRAS-dependent MEF cells. |
| PC-24267 |
SOF-436
Ras inhibitor
|
SOF-436 is a small molecule covalent KRAS inhibitor with IC50 of 60 uM in nucleotide exchange assays, inhibits KRAS nucleotide exchange by guanine exchange factor SOS1 and the binding of KRAS to effector protein RAF. |
| PC-24256 |
(RS)-G12Di-1
KRAS-G12D inhibitor
|
(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D. |
| PC-24185 |
Sosimerasib
Ras inhibitor
|
Sosimerasib is a potent, selective inhibitor of KRAS. |
