| Cat. No. |
Product Name |
Information |
| PC-45673 |
ARS-853
KRAS G12C inhibitor
|
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM. |
| PC-45476 |
K-Ras G12C-IN-1
KRAS G12C inhibitor
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| PC-23931 |
ISM061-022
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor with IC50 values in the micromolar range, shows selectivity toward certain KRAS mutants. |
| PC-23930 |
ISM061-018-2
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor, exhibits substantial binding affinity to KRAS-G12D with SPR Kd of 1.4 uM, exhibits broad activity across KRAS mutants. |
| PC-23830 |
Dual SOS1 and SOS2 binder 1
SOS1/SOS2 binder
|
Dual SOS1 and SOS2 binder 1 is a dual SOS1 and SOS2 binder. |
| PC-23829 |
SOS2 binder 1
SOS2 binder
|
SOS2 binder 1 is a selective quinazoline-based compound that binds to the catalytic site of SOS2 with SPR KD of 4.6 uM, shows no binding to SOS1 up 200 uM. |
| PC-23776 |
INCB159020
KRAS G12D inhibitor
|
INCB159020 is a potent, selective KRAS G12D inhibitor with SPR binding Kd of 22 nM, IC50 of 33 nM in HTRF pERK cell assays. |
| PC-23212 |
ADT-1004
Ras inhibitor
|
ADT-1004 is an orally bioavailable prodrug of ADT-007, potent, selective pan-RAS inhibitor, selectively inhibits PDAC cells with mutant KRAS, does not impact the growth of tumors from RAS WT PDAC cells. |
| PC-22982 |
Sotorasib (AMG-510)
KRAS G12C inhibitor
|
Sotorasib (AMG510) racemate s a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM. |
| PC-22872 |
KRAS G12C inhibitor 143D
KRAS G12C inhibitor
|
143D is a highly potent and selective, BBB-permeable KRAS G12C inhibitor, inhibits the binding of KRASG12C and SOS1 with IC50 of 21.1 nM. |
| PC-22827 |
LY3499446 mesylate
KRAS G12C inhibitor
|
LY3499446 mesylate is a potent, selective inhibitor of KRAS G12C. |
| PC-22826 |
LY3499446
KRAS G12C inhibitor
|
LY3499446 is a potent, selective inhibitor of KRAS G12C. |
