| Cat. No. |
Product Name |
Information |
| PC-72314 |
KRAS G12C Pipetide
|
LVVVGACGVGK |
| PC-72222 |
Chelidonine
STK19 inhibitor
|
Chelidonine (Stylophorin, (+)-Chelidonine) is a potent, selective, ATP-competitive inhibitor of STK19 kinase activity, inhibits STK19-mediated NRAS S89 phosphorylation with IC50 of 125 nM, inhibits NRAS-mediated signaling. |
| PC-72019 |
Rasarfin
Ras-ARF6 inhibitor
|
Rasarfin is a novel dual Ras and ARF6 inhibitor, selectively inhibits small G proteins Ras and ARF6 with IC50 of 7 and 0.7 uM. |
| PC-38332 |
Ras binder compound 3
|
Ras binder compound 3 is a switch-II binding ligand which binds Ras GDP and GTP states, inhibit PI3K activation in vitro.. |
| PC-38331 |
Ras binder 2C07
|
Ras binder 2C07 is a switch-II binding ligand which binds Ras GDP and GTP states.. |
| PC-38328 |
KRpep-2d
|
KRpep-2d (Ac-RRCPLYISYDPVCRR-NH2) is a potent, selective, cell-membrane permeable, cyclic peptide inhibitor of K-Ras(G12D) with IC50 of 1.6 nM, >10-fold selectivity over WT and G12C KRas. |
| PC-36140 |
KRAS inhibitor 11
|
KRAS inhibitor 11 is a first-in-class, high-affinity, noncovalent allosteric KRAS inhibitor, disrupts KRAS-Raf interaction with Kd of 1.2 uM. |
| PC-36032 |
(S)-BAY-293
|
(S)-BAY-293 (BAY293 S-enantiomer) is the S-enantiomer of BAY-293 as a negative control compound.. |
| PC-36031 |
BAY-293 racemate
|
BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM).. |
| PC-35953 |
KRAS G12C inhibitor 11
|
KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM. |
| PC-35921 |
RAS activator compound 1
|
RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM. |
| PC-35878 |
KRAS-G12C inhibitor 13
|
KRAS-G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays. |
