| Cat. No. |
Product Name |
Information |
| PC-60885 |
UC-773587
SOS1-Ras inhibitor
|
UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction. |
| PC-70154 |
ML-162
|
ML-162 (ML162) is a small-molecule probe that selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM. |
| PC-45721 |
ML-098
Ras activator
|
ML-098 (CID-7345532) is a small molecule pan activator families of Ras-related GTPases (EC50=77-588 nM for Rab7, Rab-2A, Cdc42, Rac1). |
| PC-45673 |
ARS-853
KRAS G12C inhibitor
|
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM. |
| PC-45476 |
K-Ras G12C-IN-1
KRAS G12C inhibitor
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| PC-22656 |
HRS-4642
KRAS G12D inhibitor
|
HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor with SPR KD of 0.083 nM, >20-fold selective over wild-type KRAS and KRAS G12C. |
| PC-22632 |
MK-1084
KRAS G12C inhibitor
|
MK-1084 is a potent, orally bioavailable and low-dose KRAS G12C covalent inhibitor with IC50 of 1.2 nM in in vitro guanine nucleotide exchange assay, and 9 nM in cell-based phospho-ERK1/2 assay with H358 cell line. |
| PC-22631 |
LUNA18
KRAS inhibitor
|
LUNA18 (LUNA-18) is a highly potent, 11-mer cyclic peptide inhibitor for the intracellular tough target RAS with IC50 of <2 nM for KRAS G12D-SOS1 PPI, KD of 0.043 nM for KRAS G12C. |
| PC-22626 |
Glecirasib
KRAS G12C inhibitor
|
Glecirasib (JAB-21822) is a highly selective, covalent oral KRAS G12C inhibitor, demonstrated promising clinical activity in NSCLC and CRC. |
| PC-22562 |
RMC-0331
SOS1 inhibitor
|
RMC-0331 (RMC-023, RM-023) is a potent, selective, and orally bioavailable SOS1 inhibitor, disrupts the critical interaction between KRAS and SOS1, blocks RAS activation. |
| PC-22561 |
HH0043
SOS1 inhibitor
|
HH0043 is a potent, orally bioavailable inhibitor of guanine nucleotide exchange factor (GEF) SOS1 with IC50 of 5.8 nM for KRAS/SOS1 binding inhibition, 54 nM for p-ERK inhibition. |
| PC-22366 |
Deltarasin
PDE6D inhibitor
|
Deltarasin is potent, specfic inhibitor of KRAS-PDEδ (PDE6D) interaction, bind to the prenyl-binding pocket of PDEδ with KD of 38 nM, inhibits oncogenic RAS signalling. |
