You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-Ras

Request The Product List ofRas Ras

Cat. No. Product Name Information
PC-21263

ERAS-5024

KRAS G12D inhibitor

ERAS-5024 (ERAS5024) is a potent and selective KRAS G12D inhibitor with IC50 of 0.86 nM in RAS-RAF binding assays, inhibits ERK1/2 phosphorylation (pERK) formation with IC50 of 2.1 nM in AsPC-1 cell-based assays.
PC-21132

ACA22

KRAS inhibitor

ACA22 is a small molecule KRAS inhibitor, inhibits KRAS-mediated signal transduction in cells expressing wild type (WT) and G12D mutant KRAS.
PC-21063

RMC-4998

KRAS G12C inhibitor

RMC-4998 (RMC4998) is a tricomplex inhibitor that targets the active state or GTP-bound state of KRAS G12C, selectively inhibits the proliferation of KRASG12C mutant cells with mean IC50 of 0.28 nM.
PC-20958

AZD4747

KRAS G12C inhibitor

AZD4747 (AZD-4747) is a highly potent, selective, covalent and brain-penetrant inhibitor of KRAS G12C with IC50 of 15 nM.
PC-20884

NRAS-G4 inhibitor 18

NRAS-G4 inhibitor

NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM.
PC-20692

ACA-14

KRAS inhibitor

ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.
PC-20553

Igf2bp1 inhibitor 7773

Igf2bp1 inhibitor

Igf2bp1 inhibitor 7773 is a specific small molecule inhibitor of Igf2bp1, binds to RNA binding domains of Igf2bp1, inhibits Igf2bp1 binding of Kras 6 RNA with IC50 of 30 uM.
PC-20251

Lonafranib

Ras inhibitor

Lonafranib (SCH 66336) is a potent, selective and orally active farnesyl protein transferase (FPT) inhibitor with IC50 of 1.9 nM, 5.2 nM and 2.8 nM for H-ras, K-ras-4B and N-ras, respectively.
PC-20249

SCH53239

Ras inhibitor

SCH-53239 (SCH53239) is a small molecule inhibitor of Ras nucleotide exchange with IC50 of 0.5 uM, bind competitively with GDP in the nucleotide binding site of the Ras protein.
PC-20037

Fulzerasib

Ras inhibitor

Fulzerasib is a potent selective inhibitor of KRAS gene mutation.
PC-49554

RSC-1255

V-ATPase inhibitor

RSC-1255 (KRAS inhibitor 249C, V-ATPase inhibitor) is a Ras-mutant selective cytotoxic agent with nanomolar potency against a spectrum of Ras-mutant cancer cells (A549 (KRASG12S), IC50=73 nM), binds to V-ATPase (Kd=23 nM) and inhibits its activity.
PC-49153

G12Si-5

K-Ras(G12S) inhibitor

G12Si-5 is a specific small molecule that covalently target K-Ras(G12S) mutation, suppresses K-Ras(G12S) signaling, preferentially inhibits the growth of the K-Ras(G12S)-transduced cells with IC50 of 2.4 uM.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com