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KAL-21404358

Chemical Structure : KAL-21404358

CAS No.: 1065573-84-3

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KAL-21404358 (KAL21404358)

Catalog No.: PC-38329Not For Human Use, Lab Use Only.

KAL-21404358 (KAL21404358) is a small-molecule, allosteric inhibitor of K-Ras(G12D), binds to K-Ras(G12D) P110 site with KD of 88 uM in MST assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KAL-21404358 (KAL21404358) is a small-molecule, allosteric inhibitor of K-Ras(G12D), binds to K-Ras(G12D) P110 site with KD of 88 uM in MST assay.
    KAL-21404358 disrupts the K-RasG12D-B-Raf interaction using a NanoBiT split luciferase assay, and to impair the Raf-MEK-ERK and the PI3K-AKT signaling pathways.
    KAL-21404358 exhibited specificity for K-RasG12D over K-RasWT, H-RasWT, Rap1a, R-Ras and R-Ras2.

    Physicochemical Properties

    M.Wt 357.498
    Formula C21H31N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((3-(2-hydroxyethyl)-4-neopentylpiperazin-1-yl)methyl)quinolin-4-ol

    References

    1. Huizhong Feng, et al. Biochemistry. 2019 May 28;58(21):2542-2554.

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