ML210 (ML-210, CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS.
ML210 is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 30 nM.
ML210 displays nanomolar potency (IC50=71 nM) against immortalized BJ fibroblasts expressing HRASV12.
ML-210 binds the GPX4 selenocysteine residue.
ML210 exhibits cell-killing activity similar to RSL3 and ML162 across a panel of 821 cancer cell lines.
