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Chemical Structure : ML210
CAS No.: 1360705-96-9
Catalog No.: PC-38298Not For Human Use, Lab Use Only.
ML210 (ML-210, CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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ML210 (ML-210, CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS.
ML210 is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 30 nM.
ML210 displays nanomolar potency (IC50=71 nM) against immortalized BJ fibroblasts expressing HRASV12.
ML-210 binds the GPX4 selenocysteine residue.
ML210 exhibits cell-killing activity similar to RSL3 and ML162 across a panel of 821 cancer cell lines.
| M.Wt | 475.32 | |
| Formula | C22H20Cl2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone |
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1. Joshua A Bittker, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2011
2. Weïwer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.
3. Zhou L, et al. Small. 2021 Nov;17(47):e2103919.
4. John K Eaton, et al. Nat Chem Biol. 2020 May;16(5):497-506.
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