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Chemical Structure : KRpep-2d
Catalog No.: PC-38328Not For Human Use, Lab Use Only.
KRpep-2d (Ac-RRCPLYISYDPVCRR-NH2) is a potent, selective, cell-membrane permeable, cyclic peptide inhibitor of K-Ras(G12D) with IC50 of 1.6 nM, >10-fold selectivity over WT and G12C KRas.
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KRpep-2d (Ac-RRCPLYISYDPVCRR-NH2) is a potent, selective, cell-membrane permeable, cyclic peptide inhibitor of K-Ras(G12D) with IC50 of 1.6 nM, >10-fold selectivity over WT and G12C KRas; KRpep-2d significantly suppressed ERK-phosphorylation, downstream of K-Ras(G12D), along with A427 cancer cell proliferation at 30 μM peptide concentration.
| M.Wt | 2561.01 | |
| Formula | C108H182N44O25S2 | |
| Appearance | Solid | |
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1. Sakamoto K, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):605-611.
2. Niida A, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.
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