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Chemical Structure : VUBI1
Catalog No.: PC-38293Not For Human Use, Lab Use Only.
VUBI1 (SOS1 agonist 1) is a potent activator of SOS1 which modulates the KRAS pathway, binds directly to SOS1 (Kd=44 nM).
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VUBI1 (SOS1 agonist 1) is a potent activator of SOS1 which modulates the KRAS pathway, binds directly to SOS1 (Kd=44 nM).
VUBI1 increase nucleotide exchange on RAS in vitro at sub-micromolar concentration, rapidly enhances cellular RAS-GTP levels, and invokes biphasic signaling changes in phosphorylation of ERK 1/2 (Hela pERK ICW EC50=5.9 uM).
| M.Wt | 483.032 | |
| Formula | C26H32ClFN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Timothy R Hodges, et al. J Med Chem. 2018 Oct 11;61(19):8875-8894.
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