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VUBI1

Chemical Structure : VUBI1

CAS No.: 2245237-53-8

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VUBI1 (SOS1 activator 1)

Catalog No.: PC-38293Not For Human Use, Lab Use Only.

VUBI1 (SOS1 agonist 1) is a potent activator of SOS1 which modulates the KRAS pathway, binds directly to SOS1 (Kd=44 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VUBI1 (SOS1 agonist 1) is a potent activator of SOS1 which modulates the KRAS pathway, binds directly to SOS1 (Kd=44 nM).
    VUBI1 increase nucleotide exchange on RAS in vitro at sub-micromolar concentration, rapidly enhances cellular RAS-GTP levels, and invokes biphasic signaling changes in phosphorylation of ERK 1/2 (Hela pERK ICW EC50=5.9 uM).

    Physicochemical Properties

    M.Wt 483.032
    Formula C26H32ClFN6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-chloro-1-(4-fluoro-3,5-dimethylbenzyl)-4-(4-methylpiperazin-1-yl)-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1H-benzo[d]imidazole

    References

    1. Timothy R Hodges, et al. J Med Chem. 2018 Oct 11;61(19):8875-8894.

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