Chemical Structure : ML162
CAS No.:
1035072-16-2
ML162
(ML 162, ML-162)
Catalog No. : PC-70154Not For Human Use, Lab Use Only.
ML162 (ML-162) is a small-molecule, covalent glutathione peroxidase 4 (GPX4) inhibitor, selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.
Packing Price Stock Quantity 5 mg $88 In stock 0 1 2 3 4 5 10 mg $128 In stock 0 1 2 3 4 5 25 mg $218 In stock 0 1 2 3 4 5 50 mg $358 In stock 0 1 2 3 4 5 100 mg $528 In stock 0 1 2 3 4 5 250 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7015401
Biological Activity
ML162 (ML-162) is a small-molecule, covalent glutathione peroxidase 4 (GPX4 ) inhibitor, selectively kills cells induced to express mutant RAS , inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.
Physicochemical Properties
M.Wt
477.4
Formula
C23H22CI2N2O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide
References
1. Weïwer M, et al. Bioorg Med Chem Lett.
2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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