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NSC 658497

Chemical Structure : NSC 658497

CAS No.: 909197-38-2

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NSC 658497 (NSC658497)

Catalog No.: PC-62490Not For Human Use, Lab Use Only.

NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity.
NSC 658497 showes dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation.

Physicochemical Properties

M.Wt 438.428
Formula C20H10N2O6S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-3-(((Z)-5-(4-nitrobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)methylene)chroman-2,4-dione

References

1. Evelyn CR, et al. Chem Biol. 2014 Dec 18;21(12):1618-28.

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