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CMC2.24

Chemical Structure : CMC2.24

CAS No.: 1255639-43-0

CMC2.24 (TRB-N0224)

Catalog No.: PC-63506Not For Human Use, Lab Use Only.

CMC2.24 (TRB-N0224) is a novel tricarbonylmethane agent that inhibits the Ras-RAF-MEK-ERK pathway, inhibits Ras activation in pancreatic cancer both in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CMC2.24 (TRB-N0224) is a novel tricarbonylmethane agent that inhibits the Ras-RAF-MEK-ERK pathway, inhibits Ras activation in pancreatic cancer both in vitro and in vivo.
CMC2.24 inhibits Ras-GTP in MIA PaCa-2 cells and in pancreatic acinar explants isolated from KRas mutant mice.
CMC2.24 inhibits ERK1/2 activation in pancreatic cancer cells and xenografts, inhibits pancreatic cancer growth, inhibits the growth of pancreatic cancer xenografts.

Physicochemical Properties

M.Wt 427.456
Formula C26H21NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2E,4E)-3-hydroxy-5-(4-hydroxyphenyl)-2-((E)-3-(4-hydroxyphenyl)acryloyl)-N-phenylpenta-2,4-dienamide

References

1. Mallangada NA, et al. Mol Carcinog. 2018 Apr 23. doi: 10.1002/mc.22830.

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