Chemical Structure : Deltafluorine
CAS No.:
Deltafluorine
Catalog No.: PC-25958Not For Human Use, Lab Use Only.
Deltafluorine is a specific small molecule PDEδ inhibitor with ITC KD of 148 nM and binding IC50 of 25 nM, targeting the binding site glutamate p.E88 in PDEδ, impairs K-Ras signaling.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Deltafluorine is a specific small molecule PDEδ inhibitor with ITC KD of 148 nM and binding IC50 of 25 nM, targeting the binding site glutamate p.E88 in PDEδ, impairs K-Ras signaling.
Deltafluorine impairs Ras pathway downstream of MAPK and Akt-mTOR pathways.
Deltafluorine (5 uM) shows rong inhibitory activity in KRAS-dependent pancreatic ductal adenocarcinoma cell lines PA-TU-8902 and MIA PaCa-2 cells with an average growth inhibition of 84 ± 2% and 87 ± 4%, respectively.
Deltafluorine (15 mg/kg i.p., q.d. for 21 days) reduces tumor growt in KrasLSL.G12D/wt;Trp53fl/fl (KP) mouse model.
Physicochemical Properties
|
M.Wt
|
677.29
|
|
Formula
|
C33H42ClFN4O4S2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N1-(4-chlorobenzyl)-N1-cyclopentyl-N4-((5-(fluoromethyl)-2,6-dimethylpyridin-3-yl)methyl)-N4-(piperidin-4-ylmethyl)benzene-1,4-disulfonamide
|
References
1. Zhang R, et al. J Med Chem. 2026 Jan 7. doi: 10.1021/acs.jmedchem.5c02082.
Contact Us
sales@probechem.com
