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IACS-56676

Chemical Structure : IACS-56676

CAS No.: 3105153-34-9

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IACS-56676 (IACS56676)

Catalog No.: PC-26265Not For Human Use, Lab Use Only.

IACS-56676 is a selective and potent NRAS G12D inhibitor with target engagement IC50 of 31 nM in AlphaLISA p-ERK1/2 assays, and IC50 of 73 nM in THP1 cell viability assay, displays >100-fold selectivity for NRAS G12D over KRAS wild type.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IACS-56676 is a selective and potent NRAS G12D inhibitor with target engagement IC50 of 31 nM in AlphaLISA p-ERK1/2 assays, and IC50 of 73 nM in THP1 cell viability assay, displays >100-fold selectivity for NRAS G12D over KRAS wild type.

Physicochemical Properties

M.Wt 562.01
Formula C28H28ClF4N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((6-(5-amino-3-chloro-2-(trifluoromethyl)phenyl)-3-((1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6-yl)-1,4-dicyclopropyl-7-fluoro-1H-pyrrolo[3,2-c]pyridin-2-yl)methyl)acetamide

References

1. Cox JB, et al. ACS Med Chem Lett. 2026 Jan 22;17(2):425-432.

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