Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Kobe0065
CAS No.: 436133-68-5
Catalog No.: PC-38456Not For Human Use, Lab Use Only.
Kobe0065 is a small-molecule Ras inhibitor, competitively inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 46 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $58 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $158 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Kobe0065 is a small-molecule Ras inhibitor, competitively inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 46 uM.
Kobe0065 effectively inhibit both anchorage-dependent and -independent growth and induce apoptosis of H-rasG12V–transformed NIH 3T3 cells (IC50=0.5 uM).
Kobe0065 exhibit antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-rasG12V gene by oral administration.
| M.Wt | 449.79 | |
| Formula | C15H11ClF3N5O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide |
|
1. Shima F, et al. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7.
2. Shima F, et al. Enzymes. 2013;34 Pt. B:1-23.
3. Yoshikawa Y, et al. Cancer Lett. 2017 Dec 1;410:82-91.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
