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Chemical Structure : G12Si-5
Catalog No.: PC-49153Not For Human Use, Lab Use Only.
G12Si-5 is a specific small molecule that covalently targets K-Ras(G12S) mutation, suppresses K-Ras(G12S) signaling, preferentially inhibits the growth of the K-Ras(G12S)-transduced cells with IC50 of 2.4 uM.
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G12Si-5 is a specific small molecule that covalently targets K-Ras(G12S) mutation, suppresses K-Ras(G12S) signaling, preferentially inhibits the growth of the K-Ras(G12S)-transduced cells with IC50 of 2.4 uM.
G12Si-5 inhibits Ras signaling in A549 cells with IC50 of 3 uM, does not perturb the signaling in A375 cells (wild-type KRAS) or SW1990 cells (homozygous KRAS p.G12D).
G12Si-5 dose-dependently reduces phospho-ERK levels in Ba/F3:K-Ras(G12S) cells, also inhibits the growth of KMS20, a patient-derived myeloma cell line with a homozygous KRAS p.G12S mutation, with IC50 of 7.5 uM.
| M.Wt | 574.053 | |
| Formula | C31H29ClFN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ziyang Zhang, et al. Nat Chem Biol. 2022 Jul 21. doi: 10.1038/s41589-022-01065-9.
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