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MRTX0902

Chemical Structure : MRTX0902

CAS No.: 2654743-22-1

MRTX0902 (MRTX-0902, MRTX 0902)

Catalog No.: PC-73313Not For Human Use, Lab Use Only.

MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK).
MRTX0902 displays weak to no affinity for SOS2 with IC50 of >10 uM.
MRTX0902 exhibits promising potency, selectivity, and exposure in preclinical species.
MRTX0902 in combined with MRTX849 demonstrates durable regression in KRasG12C NSCLC and CRC PDX models.
MRTX0902 demonstrates improved efficacy with osimertinib (EGFRi), VS-6766 (RAF/MEKc) in MAPK tumor models.

Physicochemical Properties

M.Wt 388.475
Formula C22H24N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-methyl-3-(1-((4-methyl-7-morpholinopyrido[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile

References

1. Ketcham JM, et al. J Med Chem. 2022 Jul 28;65(14):9678-9690.

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