Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MRTX 0902
CAS No.: 2654743-22-1
Catalog No.: PC-73313Not For Human Use, Lab Use Only.
MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $498 | In stock | |
| 25 mg | $798 | In stock | |
| 100 mg | Get quote | ||
| 250 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK).
MRTX0902 displays weak to no affinity for SOS2 with IC50 of >10 uM.
MRTX0902 exhibits promising potency, selectivity, and exposure in preclinical species.
MRTX0902 in combined with MRTX849 demonstrates durable regression in KRasG12C NSCLC and CRC PDX models.
MRTX0902 demonstrates improved efficacy with osimertinib (EGFRi), VS-6766 (RAF/MEKc) in MAPK tumor models.
| M.Wt | 388.475 | |
| Formula | C22H24N6O | |
| CAS No. | 2654743-22-1 | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name |
(R)-2-methyl-3-(1-((4-methyl-7-morpholinopyrido[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile |
|
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
