ISM061-018-2

Chemical Structure : ISM061-018-2

Catalog No.: PC-23930Not For Human Use, Lab Use Only.

ISM061-018-2 is a potential pan-Ras inhibitor, exhibits substantial binding affinity to KRAS-G12D with SPR Kd of 1.4 uM, exhibits broad activity across KRAS mutants.

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Biological Activity

ISM061-018-2 is a potential pan-Ras inhibitor, exhibits substantial binding affinity to KRAS-G12D with SPR Kd of 1.4 uM, exhibits broad activity across KRAS mutants.

Physicochemical Properties

M.Wt	346.37
Formula	C20H15FN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(2-(2-(3-fluorophenoxy)pyrimidin-5-yl)vinyl)-5-methyl-1H-indazole

References

1. Ghazi Vakili M, et al. Nat Biotechnol. 2025 Jan 22. doi: 10.1038/s41587-024-02526-3.

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ISM061-018-2

Biological Activity

Physicochemical Properties

References

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