SOF-436

Chemical Structure : SOF-436

Catalog No.: PC-24267Not For Human Use, Lab Use Only.

SOF-436 is a small molecule covalent KRAS inhibitor with IC50 of 60 uM in nucleotide exchange assays, inhibits KRAS nucleotide exchange by guanine exchange factor SOS1 and the binding of KRAS to effector protein RAF.

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Biological Activity

Physicochemical Properties

M.Wt	373.39
Formula	C15H13F2NO4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(N-(4-cyclopropyl-3-fluorophenyl)sulfamoyl)benzenesulfonyl fluoride

References

1. Landgraf A, et al. ChemMedChem. 2025 Mar 18:e202400624.

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SOF-436

Biological Activity

Physicochemical Properties

References

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