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Chemical Structure : Deltarasin
CAS No.: 1440898-61-2
Catalog No.: PC-22366Not For Human Use, Lab Use Only.
Deltarasin is potent, specfic inhibitor of KRAS-PDEδ (PDE6D) interaction, bind to the prenyl-binding pocket of PDEδ with KD of 38 nM, inhibits oncogenic RAS signalling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Deltarasin is potent, specfic inhibitor of KRAS-PDEδ (PDE6D) interaction, bind to the prenyl-binding pocket of PDEδ with KD of 38 nM, inhibits oncogenic RAS signalling.
Deltarasin interferes with the binding of KRAS to PDEδ in cells and resulting delocalization of KRAS.
Deltarasin potently suppresses proliferation and MAPK-signalling in oncogenic KRAS-dependent PDAC cells.
Deltarasin (10 mg/kg QD, 15 mg/ kg QD and 10 mg/kg BID) impairs dose-dependent in vivo growth of xenografted pancreatic carcinoma in nude mice.
| M.Wt | 603.77 | |
| Formula | C40H37N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-1-Benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole |
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1. Leung ELH, et al. Cell Death Dis. 2018 Feb 13;9(2):216.
2. Agalioti T, et al. Nat Commun. 2017 May 16;8:15205.
3. Papke B, et al. Nat Commun. 2016 Apr 20;7:11360.
4. Zimmermann G, et al. Nature. 2013 May 30;497(7451):638-42.
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