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SIJ1772

Chemical Structure : SIJ1772

CAS No.:

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SIJ1772 (SIJ 1772)

Catalog No.: PC-21798Not For Human Use, Lab Use Only.

SIJ1772 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 77 and 96 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIJ1772 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 77 and 96 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively.
SIJ1772 attenuates phosphorylation of RAS downstream molecules (AKT and MEK) and induce apoptosis and G0/G1 cell cycle arrest on cancer cells with mtRAS.
SIJ1772 suppresses the migration, invasion, and colony formation of cancer cells harboring mtRAS.

Physicochemical Properties

M.Wt 683.71
Formula C31H32F3N9O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-Methyl-3-(1-methyl-7-((1-(1-(methylsulfonyl)piperidin-4-yl)-1H-pyrazol-4-yl)amino)-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)phenyl)-3-(trifluoromethyl)benzamide

References

1. Kim N, et al. Front Oncol. 2021 Dec 9;11:768022.

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