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Chemical Structure : RMC-0331
CAS No.: 2488788-52-7
Catalog No.: PC-22562Not For Human Use, Lab Use Only.
RMC-0331 (RMC-023, RM-023) is a potent, selective, and orally bioavailable SOS1 inhibitor, disrupts the critical interaction between KRAS and SOS1, blocks RAS activation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $548 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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RMC-0331 (RMC-023, RM-023) is a potent, selective, and orally bioavailable SOS1 inhibitor, disrupts the critical interaction between KRAS and SOS1, blocks RAS activation.
RMC-0331 (RMC-023, RM-023) blocks reloading of KRAS with GTP, and thereby inhibit RAS pathway signaling and RAS-driven cancer cell growth in vitro.
Oral administration of RM-023 produced a dose-dependent suppression of tumor RAS pathway activation in vivo and inhibited tumor growth in preclinical xenograft models of diverse RAS-addicted cancers.
| M.Wt | 499.92 | |
| Formula | C22H25ClF3N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-(4-((1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)(4-methoxytetrahydro-2H-pyran-4-yl)methanone |
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1. Andreas Buckl, et al. Cancer Res (2021) 81 (13_Supplement): 1273.
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