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SIJ1795

Chemical Structure : SIJ1795

CAS No.:

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SIJ1795 (SIJ 1795)

Catalog No.: PC-21797Not For Human Use, Lab Use Only.

SIJ1795 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 82 and 75 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIJ1795 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 82 and 75 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively.
SIJ1795 attenuates phosphorylation of RAS downstream molecules (AKT and MEK) and induce apoptosis and G0/G1 cell cycle arrest on cancer cells with mtRAS.
SIJ1795 suppresses the migration, invasion, and colony formation of cancer cells harboring mtRAS.

Physicochemical Properties

M.Wt 644.70
Formula C34H35F3N8O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(7-((3-(4-Ethylpiperazin-1-yl)phenyl)amino)-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

References

1. Kim N, et al. Front Oncol. 2021 Dec 9;11:768022.

2. Cho H, et al. J Med Chem (2018) 61:8353–73.

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