Chemical Structure : Deltaflexin3
CAS No.:
2767277-64-3
Deltaflexin3
(Deltaflexin 3)
Catalog No.: PC-22365Not For Human Use, Lab Use Only.
Deltaflexin3 is a highly potent, selective and highly soluble inhibitor of the trafficking chaperone PDE6D (PDEδ) with KD value of 6 nM, inhibits PDE6D/K-Ras binding and KRAS mutant cancer cell growth.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Deltaflexin3 is a highly potent, selective and highly soluble inhibitor of the trafficking chaperone PDE6D (PDEδ) with KD value of 6 nM, inhibits PDE6D/K-Ras binding and KRAS mutant cancer cell growth.
Deltaflexin3 displays good selectivity for PDE6D-dependent and KRAS mutant with EC50 of 6 uM for MIA PaCa-2 (KRAS-G12C mutant) cells, as compared to HRAS mutant cancer cell lines.
Deltaflexin3 with the approved drug Sildenafil synergistically inhibit intracellular binding of K-Ras to PDE6D, more potently inhibits Ras signaling and microtumor growth.
Physicochemical Properties
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M.Wt
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457.59
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Formula
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C25H36FN5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(7-(ethyl((2-(methylamino)pyrimidin-4-yl)methyl)amino)-7-oxoheptyl)-4-fluoro-N-isopropylbenzamide
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References
1. Pelin Kaya, et al. J Med Chem. 2024 May 17. doi: 10.1021/acs.jmedchem.3c02129.
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