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Chemical Structure : Deltaflexin3
Catalog No.: PC-22365Not For Human Use, Lab Use Only.
Deltaflexin3 is a highly potent, selective and highly soluble inhibitor of the trafficking chaperone PDE6D (PDEδ) with KD value of 6 nM, inhibits PDE6D/K-Ras binding and KRAS mutant cancer cell growth.
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Deltaflexin3 is a highly potent, selective and highly soluble inhibitor of the trafficking chaperone PDE6D (PDEδ) with KD value of 6 nM, inhibits PDE6D/K-Ras binding and KRAS mutant cancer cell growth.
Deltaflexin3 displays good selectivity for PDE6D-dependent and KRAS mutant with EC50 of 6 uM for MIA PaCa-2 (KRAS-G12C mutant) cells, as compared to HRAS mutant cancer cell lines.
Deltaflexin3 with the approved drug Sildenafil synergistically inhibit intracellular binding of K-Ras to PDE6D, more potently inhibits Ras signaling and microtumor growth.
| M.Wt | 457.59 | |
| Formula | C25H36FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pelin Kaya, et al. J Med Chem. 2024 May 17. doi: 10.1021/acs.jmedchem.3c02129.
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