Chemical Structure : RMC-7977
CAS No.:
2765082-12-8
RMC-7977
(RMC7977, RM-042)
Catalog No.: PC-22112Not For Human Use, Lab Use Only.
RMC-7977 is a potent, highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with Kd of 116 nM, 94.7 nM and 101 nM respectively, KRAS G12V Kd of 85 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RMC-7977 is a potent, highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with Kd of 116 nM, 94.7 nM and 101 nM respectively, KRAS G12V Kd of 85 nM.
RMC-7977 is more than tenfold more potent for KRAS than MRAS and other RAS family small GTPase proteins with high sequence identity to KRAS.
RMC-7977 exhibits similar activity for wild-type and mutant RAS variants in biochemical assays
RMC-7977 inhibits the active state of multiple RAS variants.
RMC-7977 exhibits low nanomolar potency for growth inhibition of Matrigel-embedded human KRASG12X-mutant PDAC patient-derived organoids.
RMC-7977 (50 mg/kg, po, q.o.d) inhibits tumor growth and extends survival in autochthonous models of PDAC.
Physicochemical Properties
|
M.Wt
|
865.11
|
|
Formula
|
C47H60N8O6S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
|
References
1. Urszula N Wasko, et al. bioRxiv. 2023 Dec 4:2023.12.03.569791.
Contact Us
sales@probechem.com
