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Glecirasib

Chemical Structure : Glecirasib

CAS No.: 2657613-87-9

Glecirasib (JAB-21822, JAB21822)

Catalog No.: PC-22626Not For Human Use, Lab Use Only.

Glecirasib (JAB-21822) is a highly selective, covalent oral KRAS G12C inhibitor, demonstrated promising clinical activity in NSCLC and CRC.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Glecirasib (JAB-21822) is a highly selective, covalent oral KRAS G12C inhibitor, demonstrated promising clinical activity in NSCLC and CRC.

Physicochemical Properties

M.Wt 640.04
Formula C31H26ClF4N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-(2-Amino-3,4,5,6-tetrafluorophenyl)-6-chloro-1,2-dihydro-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-2-oxo-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-1,8-naphthyridine-3-carbonitrile

References

1. Jian Li, et al. 2024 ASCO.Volume 42, Number 3_suppl

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