Glecirasib | KRAS G12C inhibitor | Probechem Biochemicals

Chemical Structure : Glecirasib

Catalog No.: PC-22626Not For Human Use, Lab Use Only.

Glecirasib (JAB-21822) is a highly selective, covalent oral KRAS G12C inhibitor, demonstrated promising clinical activity in NSCLC and CRC.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Glecirasib (JAB-21822) is a highly selective, covalent oral KRAS G12C inhibitor, demonstrated promising clinical activity in NSCLC and CRC.

M.Wt	640.04
Formula	C31H26ClF4N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(2-Amino-3,4,5,6-tetrafluorophenyl)-6-chloro-1,2-dihydro-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-2-oxo-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-1,8-naphthyridine-3-carbonitrile

1. Jian Li, et al. 2024 ASCO.Volume 42, Number 3_suppl