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Chemical Structure : RMC-6236
Catalog No.: PC-22125Not For Human Use, Lab Use Only.
RMC-6236 is a first-in-class broad-spectrum RAS (ON) multi-selective inhibits, inhibits active state of both mutant and wild-type KRAS, NRAS and HRAS variants.
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RMC-6236 is a first-in-class broad-spectrum RAS (ON) multi-selective inhibits, inhibits active state of both mutant and wild-type KRAS, NRAS and HRAS variants.
RMC-6236 exhibits potent anticancer activity across RAS-addicted cell lines, particularly those harboring mutations at codon 12 of KRAS.
Oral administration of RMC-6236 is tolerated in vivo and drives profound tumor regressions across multiple tumor types in a mouse clinical trial with KRASG12X xenograft models.
| M.Wt | 811.06 | |
| Formula | C44H58N8O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jiang J, et al. Cancer Discov. 2024 Apr 9:OF1-OF24.
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