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Chemical Structure : ACBI1
CAS No.: 2375564-55-7
Catalog No.: PC-73152Not For Human Use, Lab Use Only.
ACBI1 is a potent and cooperative degrader (PROTAC) of BAF ATPase subunits SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
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| 100 mg | Get quote |
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ACBI1 is a potent and cooperative degrader (PROTAC) of BAF ATPase subunits SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM, respectively.
ACBI1 is composed of a bromodomain ligand, linker, and the E3 ubiquitin ligase von Hippel-Lindau (VHL).
ACBI1 induced antiproliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells, and in AML cells dependent on SMARCA4 ATPase activity.
| M.Wt | 936.11 | |
| Formula | C49H58FN9O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO (93.6 mg/mL in DMSO) |
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| Chemical Name/SMILES |
(2S,4R)-N-(2-(2-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide |
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1. Farnaby W, et al. Nat Chem Biol. 2019 Jul;15(7):672-680.
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