Catalog No.: PC-73152Not For Human Use, Lab Use Only.
ACBI1 is a potent and cooperative degrader (PROTAC) of BAF ATPase subunits SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM, respectively.
ACBI1 is a potent and cooperative degrader (PROTAC) of BAF ATPase subunits SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM, respectively.
ACBI1 is composed of a bromodomain ligand, linker, and the E3 ubiquitin ligase von Hippel-Lindau (VHL).
ACBI1 induced antiproliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells, and in AML cells dependent on SMARCA4 ATPase activity.
