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Chemical Structure : ACHP hydrochloride
CAS No.: 406209-26-5
Catalog No.: PC-43364Not For Human Use, Lab Use Only.
ACHP hydrochloride is a potent and specific inhibitor for IKK-β (IKK2) with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ACHP hydrochloride is a potent and specific inhibitor for IKK-β (IKK2) with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM.
ACHP exhibits good selectivity over other kinases, such as IKK3, Syk and MKK4 (IC50>20 uM).
ACHP inhibits TNFα-induced RANTES production in A549 cells with IC50 of 40 nM, inhibits NF-κB-dependent reporter gene activation in TNFα -activated HEK293 cells and PMA/calcium ionophore-activated Jurkat T cells.
ACHP demonstrates in vivo anti-inflammatory assays (1mg/kg, po) in arachidonic acid-induced ear edema model in mice.
ACHP also inhibits TNF-α-induced HIV-1 replication in latently infected cells with EC50 of 0.56 uM.
| M.Wt | 400.9018 | |
| Formula | C21H25ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Pyridinecarbonitrile, 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-, hydrochloride (1:1) |
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1. Victoriano AF, et al. Antimicrob Agents Chemother. 2006 Feb;50(2):547-55.
2. Murata T, et al. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4019-22.
3. Sanda T, et al. Leukemia. 2006 Apr;20(4):590-8.
4. Mia MM, et al. J Cell Mol Med. 2015 Dec;19(12):2780-92.
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