| Cat. No. |
Product Name |
Information |
| PC-21476 |
Shikonin
NEMO/IKKβ inhibitor, PKM2 inhibitor
|
Shikonin is a specific inhibitor of the IKKβ/NEMO complex PPI with IC50 of 170 nM, also a potent TMEM16A chloride channel inhibitor (IC50=6.5 uM) and specific pyruvate kinase M2 (PKM2) inhibitor. |
| PC-49484 |
AFN700
IKKβ inhibitor
|
AFN700 (AFN 700) is a specific inhibitor of IκKβ kinase with IC50 of 0.51 uM in NF-kB reporter gene assays, inhibits TNF-a secretion produced by THP-1 cells (3h treatment with 100 ng/ml Pam3CSK4) with IC50 of 0.89 uM. |
| PC-38528 |
AZ13102909
TBK1 inhibitor
|
AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases. |
| PC-73128 |
BAY-985
TBK1/IKKε inhibitor
|
BAY-985 (BAY985) is a potent and highly selective TBK1/IKKε inhibitor with IC50 of 2 nM (low ATP assay). |
| PC-38171 |
GSK8612
TBK1 inhibitor
|
GSK8612 (GSK-8612) is a highly selective, potent TBK1 inhibitor, inhibits recombinant TBK1 with pIC50 of 6.8 in biochemical functional assays. |
| PC-35769 |
SR12343
IKKβ inhibitor
|
SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays. |
| PC-35736 |
PIAA
TBK1/IKKε inhibitor
|
PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells. |
| PC-63330 |
IKK16
IKK inhibitor
|
IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. |
| PC-43364 |
ACHP hydrochloride
IKK2 inhibitor
|
ACHP hydrochloride is a potent and specific inhibitor for IKK-β (IKK2) with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM. |
| PC-43329 |
BI605906
IKKβ inhibitor
|
BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK. |
| PC-43042 |
TBK1-IN-1
TBK1/IKKε inhibitor
|
TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM. |
| PC-63117 |
IKK2-IN-8
IKK2 inhibitor
|
IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM). |
