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Cat. No. Product Name Information
PC-49484

AFN700

IKKβ inhibitor

AFN700 (AFN 700) is a specific inhibitor of IκKβ kinase with IC50 of 0.51 uM in NF-kB reporter gene assays, inhibits TNF-a secretion produced by THP-1 cells (3h treatment with 100 ng/ml Pam3CSK4) with IC50 of 0.89 uM.
PC-38528

AZ13102909

TBK1 inhibitor

AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases.
PC-73128

BAY-985

TBK1/IKKε inhibitor

BAY-985 (BAY985) is a potent and highly selective TBK1/IKKε inhibitor with IC50 of 2 nM (low ATP assay).
PC-35736

PIAA

PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells.
PC-63330

IKK16

IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.
PC-43364

ACHP hydrochloride

ACHP hydrochloride is a potent and specific inhibitor for IKK-β with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM, exhibits good selectivity over other kinases, such as IKK3, Syk and MKK4 (IC50>20 uM).
PC-43329

BI605906

BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK.
PC-43042

TBK1-IN-1

TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM.
PC-63117

IKK2-IN-8

IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM).
PC-63116

IKK2-IN-9

IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM).
PC-63015

TBK1-IKKε inhibitor II

TBK1-IKKε inhibitor II is a potent, selective dual inhibitor of TBK1/IKKε with IC50 of 13 nM/59 nM, respectively.
PC-61094

PHA-408

A novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM, 350-fold selectivity over IKK-1.

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