Cat. No. |
Product Name |
Information |
PC-49484 |
AFN700
IKKβ inhibitor
|
AFN700 (AFN 700) is a specific inhibitor of IκKβ kinase with IC50 of 0.51 uM in NF-kB reporter gene assays, inhibits TNF-a secretion produced by THP-1 cells (3h treatment with 100 ng/ml Pam3CSK4) with IC50 of 0.89 uM. |
PC-38528 |
AZ13102909
TBK1 inhibitor
|
AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases. |
PC-73128 |
BAY-985
TBK1/IKKε inhibitor
|
BAY-985 (BAY985) is a potent and highly selective TBK1/IKKε inhibitor with IC50 of 2 nM (low ATP assay). |
PC-35736 |
PIAA
|
PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells. |
PC-63330 |
IKK16
|
IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. |
PC-43364 |
ACHP hydrochloride
|
ACHP hydrochloride is a potent and specific inhibitor for IKK-β with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM, exhibits good selectivity over other kinases, such as IKK3, Syk and MKK4 (IC50>20 uM). |
PC-43329 |
BI605906
|
BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK. |
PC-43042 |
TBK1-IN-1
|
TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM. |
PC-63117 |
IKK2-IN-8
|
IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM). |
PC-63116 |
IKK2-IN-9
|
IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM). |
PC-63015 |
TBK1-IKKε inhibitor II
|
TBK1-IKKε inhibitor II is a potent, selective dual inhibitor of TBK1/IKKε with IC50 of 13 nM/59 nM, respectively. |
PC-61094 |
PHA-408
|
A novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM, 350-fold selectivity over IKK-1. |