TBK1-IN-1

You are here:Home-Chemical Inhibitors & Agonists-NF-κB Pathway-IκB kinase (IKK)-TBK1-IN-1

Chemical Structure : TBK1-IN-1

CAS No.: 1292310-49-6

Catalog No.: PC-43042Not For Human Use, Lab Use Only.

TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM.

Packing	Price	Stock
5 mg	$178	In stock
10 mg	$258	In stock
25 mg	$458	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM.
TBK1-IN-1 inhibits IRF3 nuclear translocation with IC50 of 95 nM, but does not significantly inhibits cell proliferation in some NSCLC, pancreatic, and colorectal cell lines.

Physicochemical Properties

M.Wt	457.5243
Formula	C26H27N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 21.5 mg/mL
Chemical Name/SMILES	Benzonitrile, 5-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-

References

1. Muvaffak A, et al. Mol Cancer Res. 2014 Jul;12(7):1055-66.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

TBK1-IN-1

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.