IKK2-IN-9 |CAS:1266240-89-4 Probechem Biochemicals

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Chemical Structure : IKK2-IN-9

IKK2-IN-9

Catalog No.: PC-63116Not For Human Use, Lab Use Only.

IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM).

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Biological Activity

IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM).
IKK2-IN-9 inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 0.22 uM.
IKK2-IN-9 dose-dependently inhibist the TNF-α response in murine model of acute inflammation.

Physicochemical Properties

M.Wt	394.497
Formula	C20H22N6OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(3-(5-(ethylamino)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl)phenyl)ethyl)acetamide

References

1. Dyckman AJ, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6.

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IKK2-IN-9

Biological Activity

Physicochemical Properties

References

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